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. 2023 Mar;60(3):379-386.
doi: 10.1007/s00592-022-02013-8. Epub 2022 Dec 20.

Regional divergence and time trends in the prevalence of gestational diabetes mellitus: a national Danish cohort study

Cathrine M Scheuer  1 , Maria H Andersen  2 , Elisabeth R Mathiesen  3   4 , Lene Ringholm  3 , Clara L Müller  2 , Jun-Mei Truong  2 , Michelle M Lie-Olesen  2 , Martin Overgaard  5   6 , H David McIntyre  7 , Dorte M Jensen  8   9   6 , Peter Damm  4   10 , Tine D Clausen  2   4
Affiliations

Regional divergence and time trends in the prevalence of gestational diabetes mellitus: a national Danish cohort study

Cathrine M Scheuer et al. Acta Diabetol. 2023 Mar.

Abstract

Aims: To evaluate the prevalence and time trends of gestational diabetes mellitus (GDM) across the five regions of Denmark with uniform national guidelines for screening and diagnosing GDM.

Methods: This register-based national cohort study included 287,684 births from 2013 to 2017. Trends in GDM prevalence over time and differences between the five regions were evaluated. Crude and adjusted odd ratios (ORs) for GDM were calculated including potential confounding clinical risk factors as age, BMI, educational level, marital status, parity, country of origin and assisted reproduction.

Results: From 2013 to 2017, GDM prevalence in Denmark increased by 7% per year (OR 1.07, 95% CI 1.06-1.09, P < 0.001). GDM prevalence varied considerably between regions and ranged from 3.0 to 5.9% in 2017, corresponding to a maximal regional difference of 97%. In crude analyses, the risk of GDM in 2017 was significantly different in four of five regions compared to the remaining regions (OR ranging from 0.60 to 1.55), and these differences persisted after adjusting for confounding clinical risk factors (adjusted OR: 0.59-1.45).

Conclusion: The prevalence of GDM increased over time in all Danish regions with substantial regional divergence. Up to a 97%, difference in GDM prevalence was observed between Danish regions, which was not explained by available clinical risk factors. This occurred despite national guidelines and raises the question of whether regional variations in screening efficacy, diagnostic procedures or inequality in clinical health care access may explain the observed differences.

Keywords: Denmark; Gestational diabetes mellitus; Pregnancy; Prevalence; Registries.

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Conflict of interest statement

The authors declare that there are no competing interests.

Figures

Fig. 1
Fig. 1
Regional GDM prevalence in Denmark from 2013 to 2017
See this image and copyright information in PMC

References

    1. Wang H, Li N, Chivese T, et al. IDF diabetes atlas estimation of global and regional gestational diabetes mellitus prevalence for 2021 by international association of diabetes in pregnancy study group’s criteria. Diabetes Res Clin Pract. 2022;183:109050. doi: 10.1016/j.diabres.2021.109050. - DOI - PubMed
    1. Paulo MS, Abdo NM, Bettencourt-Silva R, et al. Gestational diabetes mellitus in Europe: a systematic review and meta-analysis of prevalence studies. Front Endocrinol (Lausanne) 2021;12(December):1–20. - PMC - PubMed
    1. Benhalima K, Damm P, Van Assche A, et al. Screening for gestational diabetes in Europe: where do we stand and how to move forward? A scientific paper commissioned by the European Board & College of Obstetrics and Gynaecology (EBCOG) Eur J Obstet Gynecol Reprod Biol. 2016;201:192–196. doi: 10.1016/j.ejogrb.2016.04.002. - DOI - PubMed
    1. Sandbjerg Guideline (2014) Gestational Diabetes Mellitus: Screening and diagnosis. Danish Society of Obstetrics and Gynaecology. http://gynobsguideline.dk/wp/wp-content/uploads/2013/02/GDM-Sandbjerg-20...
    1. Jensen DM, Mølsted-Pedersen L, Beck-Nielsen H, et al. Screening for gestational diabetes mellitus by a model based on risk indicators: a prospective study. Am J Obstet Gynecol. 2003;189(5):1383–1388. doi: 10.1067/S0002-9378(03)00601-X. - DOI - PubMed

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