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. 2022 Dec 20;20(1):404.
doi: 10.1186/s12957-022-02846-1.

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Mingkun Zhao #  1 , Minzhi Lv #  2 , Yuan Fang  1 , Aobo Zhuang  1   3 , Qian Wu  1 , Hanxing Tong  3 , Weiqi Lu  3 , Yong Zhang  4
Affiliations

Sarcopenia is associated with worse surgical complications but not relapse-free survival and overall survival in patients with retroperitoneal liposarcoma

Mingkun Zhao et al. World J Surg Oncol. .

Abstract

Objective: This investigation aimed to explore the relationship between sarcopenia and severe postoperative complications, relapse-free survival (RFS), and overall survival (OS) in patients with retroperitoneal liposarcoma (RLPS).

Material and methods: This retrospective study included 72 RLPS patients (47 men, 25 women; mean age, 57.49 years, SD 10.92) who had abdominal CT exams. Clinical information was recorded, including RLPS characteristics (histologic subtypes, grade, size), laboratory assessment (ALB, PALB, A/G, Hb, SCr), relapse-free survival, overall survival, and postoperative complications. The relationships between those variables and RFS and OS were analyzed using Cox proportional hazard models.

Results: There were 8 severe postoperative complications (Clavien-Dindo grade > 2). The chi-square test showed sarcopenia was associated with severe postoperative complications (P = 0.011). In multivariate analysis, sarcopenia was not associated with relapse-free survival (P = 0.574) and overall survival (P = 0.578).

Conclusions: Sarcopenia predicts worse surgical complications but does not affect relapse-free survival and overall survival.

Keywords: Overall survival; Relapse-free survival; Retroperitoneal liposarcoma; Sarcopenia; Surgery complication.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Local relapse-free survival in patients by A all patients, B sarcopenia, and C histologic subtypes
Fig. 2
Fig. 2
Overall survival in patients by A all patients, B sarcopenia, and C symptoms
See this image and copyright information in PMC

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Supplementary concepts