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. 2022 Dec 8;12(54):35221-35226.
doi: 10.1039/d2ra07065k. eCollection 2022 Dec 6.

Visible light-induced photoredox catalyzed C-N coupling of amides with alcohols

Shraddha Tivari  1 , Pravin K Singh  1 , Praveen P Singh  2 , Vishal Srivastava  1
Affiliations

Visible light-induced photoredox catalyzed C-N coupling of amides with alcohols

Shraddha Tivari et al. RSC Adv. .

Abstract

A visible-light-mediated method for the construction of N-monoalkylated products from easily available benzamides and benzyl alcohol in the presence of eosin Y has been developed. The reaction proceeded smoothly, for a wide range of derivatives of benzamides and benzyl alcohols, to give the desired products in good to excellent yields. Biological studies, such as those on drug-likeness and molecular docking, are carried out on the molecules.

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Conflict of interest statement

There are no conflicts to declare.

Figures

Fig. 1
Fig. 1. Some commercially available amide drugs.
Scheme 1
Scheme 1. Photoredox catalyzed C–N coupling of amides with alcohols.
Scheme 2
Scheme 2. Plausible mechanism for C–N coupling of amides with alcohols.
Fig. 2
Fig. 2. Ligand N-benzylbenzamide embedded in the active site of 1U3U protein.
See this image and copyright information in PMC

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