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Case Reports
. 2022 Nov 16;14(11):e31585.
doi: 10.7759/cureus.31585. eCollection 2022 Nov.

Re-irradiation of Pediatric Medulloblastoma: A Case Report and Systematic Review

Georgios Giakoumettis  1 , Artemis Mantzavinou  2 , Georgios Moschos  3 , Dimitrios Giakoumettis  4 , Antonio Capizzello  3
Affiliations
Case Reports

Re-irradiation of Pediatric Medulloblastoma: A Case Report and Systematic Review

Georgios Giakoumettis et al. Cureus. .

Abstract

Despite the optimal treatment given to children with medulloblastoma, many relapses are seen after combining treatments. Re-irradiation is part of salvage therapy for children who relapse and might provide long-term disease control. Nevertheless, it is challenging because there is a concern about exceeding radiation tolerances and late treatment toxicities. Re-irradiation is an option for many brain tumors, including medulloblastoma in children. This study presents a case of recurrent medulloblastoma treated with re-irradiation. A systematic review of the literature provided up-to-date data on the re-irradiation of medulloblastoma in children. This study aims to contribute to the scarce literature on the treatment strategy, which may help improve patients' outcomes.

Keywords: medulloblastoma; pediatric brain tumour; posterior fossa mass; radiotherapy; reirradiation.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Axial Images of MRI T1WI sequence with contrast at the same level. A: Recurrence of medulloblastoma, the new site at the right temporal pole. B: Three months after focused re-irradiation of the tumour.
Figure 2
Figure 2. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Flow Chart
See this image and copyright information in PMC

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