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Case Reports
. 2022 Nov 16;14(11):e31559.
doi: 10.7759/cureus.31559. eCollection 2022 Nov.

A Case Report of Exfoliative Bullous Rash Following AstraZeneca Vaccine

Usman Saleem  1 , Elizabeth S Goh  1
Affiliations
Case Reports

A Case Report of Exfoliative Bullous Rash Following AstraZeneca Vaccine

Usman Saleem et al. Cureus. .

Abstract

The coronavirus disease 2019 (COVID-19) pandemic has affected globally; but thanks to vaccines, the effect has been countered with the help of a vaccination programme. We report a case of exfoliative bullous rash in a 69-year-old lady admitted to the acute medicine unit with complaints of rash post-AstraZeneca (AZ) vaccine administration. The rash initially started under her breast and had spread to other parts of the body without mucosal involvement. She was noted to have neutrophilia and raised inflammatory markers and subsequently commenced on antibiotics. Histology showed sub-epidermal blistering but negative immunofluorescence which excluded immune-bullous disease. A significant improvement was seen, and the presentation subsided after treatment with antibiotics and emollient therapy.

Keywords: astra zeneca covid-19 vaccine; covid-19; exfoliative bullous rash; side effect post vaccination; vaccine related rash.

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Conflict of interest statement

The authors have declared that no competing interests exist.

Figures

Figure 1
Figure 1. Exfoliative bullous rash presentation
Figure 2
Figure 2. B/L lower limbs involvement with plaques and non-blanching papules
B/L: Bilateral
Figure 3
Figure 3. Rash involved neck and face but not oral mucosa
Figure 4
Figure 4. Rash involving back with scalding of the surrounding skin
Figure 5
Figure 5. Flexor surface of the arm
Figure 6
Figure 6. Extensor surface of the arm
See this image and copyright information in PMC

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