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. 2023 Jan 9;24(1):e56184.
doi: 10.15252/embr.202256184. Epub 2022 Dec 21.

Current developments in antibiotic discovery: Global microbial diversity as a source for evolutionary optimized anti-bacterials: Global microbial diversity as a source for evolutionary optimized anti-bacterials

Julian D Hegemann  1   2 , Joy Birkelbach  1   2 , Sebastian Walesch  1   2 , Rolf Müller  1   2   3
Affiliations

Current developments in antibiotic discovery: Global microbial diversity as a source for evolutionary optimized anti-bacterials: Global microbial diversity as a source for evolutionary optimized anti-bacterials

Julian D Hegemann et al. EMBO Rep. .

Abstract

In light of the pending antibiotic resistance crisis, we need to go back to nature and search for novel anti-bacterial compounds.

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Figures

Figure 1
Figure 1. Soil samples can be a rich source of microbial diversity
Bacteria easy to isolate are frequently studied, while bacteria that are more difficult to grow are less frequently sampled and thus often neglected by researchers.Source data are available online for this figure.
Figure 2
Figure 2. Simplified schematic representation of how the iChip technology can be utilized to cultivate bacteria from the soil that could not be isolated under standard laboratory conditions before
Source data are available online for this figure.
Figure 3
Figure 3. Schematic general workflow for genome mining for biosynthetic gene clusters homologous to a known cluster
Source data are available online for this figure.
Figure 4
Figure 4. Schematic of the general workflow leading from the initial sample collection from the environment to the generation of a metagenomic library
Source data are available online for this figure.
See this image and copyright information in PMC

References

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    1. Antimicrobial Resistance Collaborators (2022) Global burden of bacterial antimicrobial resistance in 2019: a systematic analysis. Lancet 399: 629–655 - PMC - PubMed
    1. Baumann S, Herrmann J, Raju R, Steinmetz H, Mohr KI, Hüttel S, Harmrolfs K, Stadler M, Müller R (2014) Cystobactamids: myxobacterial topoisomerase inhibitors exhibiting potent antibacterial activity. Angew Chem Int Ed 53: 14605–14609 - PubMed
    1. Cao P, Wei X, Awal RP, Müller R, Wall D (2019) A highly polymorphic receptor governs many distinct self‐recognition types within the Myxococcales order. MBio 10: e02751‐18 - PMC - PubMed
    1. Garcia R, Gerth K, Stadler M, Dogma IJ Jr, Müller R (2010) Expanded phylogeny of myxobacteria and evidence for cultivation of the ‘unculturables’. Mol Phylogenet Evol 57: 878–887 - PubMed

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