Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 Apr;39(4):821-830.
doi: 10.1007/s10554-022-02784-9. Epub 2022 Dec 21.

Cardiac magnetic resonance T2* mapping in patients with COVID-19 pneumonia is associated with serum ferritin level?

Sercin Ozkok  1   2 , Hatice Ozge Ciftci  3 , Nursen Keles  4 , Mesut Karatas  5 , Kemal Emrecan Parsova  4 , Erkan Kahraman  4 , Furkan Durak  6 , Kerem Pekkan  7 , Cevdet Ugur Kocogulları  8 , Nurettin Yiyit  9
Affiliations

Cardiac magnetic resonance T2* mapping in patients with COVID-19 pneumonia is associated with serum ferritin level?

Sercin Ozkok et al. Int J Cardiovasc Imaging. 2023 Apr.

Abstract

The coronavirus disease of 2019 (COVID-19)-related myocardial injury is an increasingly recognized complication and cardiac magnetic resonance imaging (MRI) has become the most commonly used non-invasive imaging technique for myocardial involvement. This study aims to assess myocardial structure by T2*-mapping which is a non-invasive gold-standard imaging tool for the assessment of cardiac iron deposition in patients with COVID-19 pneumonia without significant cardiac symptoms. Twenty-five patients with COVID-19 pneumonia and 20 healthy subjects were prospectively enrolled.Cardiac volume and function parameters, myocardial native-T1, and T2*-mapping were measured. The association of serum ferritin level and myocardial mapping was analyzed. There was no difference in terms of cardiac volume and function parameters. The T2*-mapping values were lower in patients with COVID-19 compared to controls (35.37 [IQR 31.67-41.20] ms vs. 43.98 [IQR 41.97-46.88] ms; p < 0.0001), while no significant difference was found in terms of native-T1 mapping value(p = 0.701). There was a positive correlation with T2*mapping and native-T1 mapping values (r = 0.522, p = 0.007) and negative correlation with serum ferritin values (r = - 0.653, p = 0.000), while no correlation between cardiac native-T1 mapping and serum ferritin level. Negative correlation between serum ferritin level and T2*-mapping values in COVID-19 patients may provide a non-contrast-enhanced alternative to assess tissue structural changes in patients with COVID-19. T2*-mapping may provide a non-contrast-enhanced alternative to assess tissue alterations in patients with COVID-19. Adding T2*-mapping cardiac MRI in patients with myocardial pathologies would improve the revealing of underlying mechanisms. Further in vivo and ex vivo animal or human studies designed with larger patient cohorts should be planned.

Keywords: COVID-19; Cardiac magnetic resonance imaging (MRI); Ferritin; Myocarditis.

PubMed Disclaimer

Conflict of interest statement

The authors have no relevant financial or non-financial interests to disclose.

Figures

Fig. 1
Fig. 1
Multiparametric cardiac magnetic resonance imaging in a 47-year-old male patient with COVID-19. The same slices of short axis view on basal, mid-ventricular, and apical segments (left-to-right) for b-SSPF, native-T1, and T2* mapping images. Native-T1 and T2* mapping values were calculated for the entire ventricle as 1028 ± 8 ms and 41 ± 6 ms, respectively
Fig. 2
Fig. 2
Correlation of mean T2* mapping value with serum ferritin (a, left) and native-T1 mapping (b, right) values
Fig. 3
Fig. 3
Correlation between mean native-T1 mapping value with serum ferritin
See this image and copyright information in PMC

Similar articles

See all similar articles

References

    1. World Health Organization (2020) Coronavirus disease 2019 (COVID-19) situation report-51. Available at: https://www.who.int/docs/default-source/coronaviruse/situation-reports/2.... Accessed 28 Jan 2021
    1. World Health Organization (2021) Actualización epidemiológica semanal COVID-19. World Health Organization, pp 1–3
    1. Chakurkar V, Rajapurkar M, Lele S, et al. Increased serum catalytic iron may mediate tissue injury and death in patients with COVID-19. Sci Rep. 2021;11(1):19618. doi: 10.1038/s41598-021-99142-x. - DOI - PMC - PubMed
    1. Paramasivam A, Priyadharsini JV, Raghunandhakumar S, Elumalai P. A novel COVID-19 and its effects on cardiovascular disease. Hypertens Res. 2020;43(7):729–730. doi: 10.1038/s41440-020-0461-x. - DOI - PMC - PubMed
    1. Chen T, Wu D, Chen H, Yan W, Yang D, Chen G, Ma K, Xu D, Yu H, Wang H, Wang T, Guo W, Chen J, Ding C, Zhang X, Huang J, Han M, Li S, Luo X, Zhao J, Ning Q. Clinical characteristics of 113 deceased patients with coronavirus disease 2019: retrospective study. BMJ. 2020;26(368):m1091. doi: 10.1136/bmj.m1091. - DOI - PMC - PubMed