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. 2023 Apr:21:28-39.
doi: 10.1016/j.ijpddr.2022.12.002. Epub 2022 Dec 13.

Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited

Stephanie L Macdonald  1 , Ghazanfar Abbas  1 , Abdul Ghafar  1 , Charles G Gauci  1 , Jenni Bauquier  1 , Charles El-Hage  1 , Brett Tennent-Brown  1 , Edwina J A Wilkes  2 , Anne Beasley  3 , Caroline Jacobson  4 , Lucy Cudmore  5 , Peter Carrigan  5 , John Hurley  6 , Ian Beveridge  1 , Kristopher J Hughes  7 , Martin K Nielsen  8 , Abdul Jabbar  9
Affiliations

Egg reappearance periods of anthelmintics against equine cyathostomins: The state of play revisited

Stephanie L Macdonald et al. Int J Parasitol Drugs Drug Resist. 2023 Apr.

Abstract

Cyathostomins are the most common and highly prevalent parasites of horses worldwide. Historically, the control of cyathostomins has mainly relied on the routine use of anthelmintic products. Increasing reports on anthelmintic resistance (AR) in cyathostomins are concerning. A potential method proposed for detecting emerging AR in cyathostomins has been estimating the egg reappearance period (ERP). This paper reviews the data available for the ERP of cyathostomins against the three major classes of anthelmintics, macrocyclic lactones, tetrahydropyrimidines, and benzimidazoles. Published peer-reviewed original research articles were obtained from three databases (PubMed, CAB Direct and Web of Science) and were evaluated for their inclusion in a systematic review. Subsets of articles were then subjected to a review of ERP data. A total of 54 (of 134) studies published between 1972 and 2022 met the criteria for inclusion in the systematic review. Until the beginning of 2022, there was no agreed definition of the ERP; eight definitions of ERP were identified in the literature, complicating the comparison between studies. Additionally, potential risk factors for the shortening of the ERP, including previous anthelmintic use and climate, were frequently not described. Reports of shortened ERP for moxidectin and ivermectin are frequent: 20 studies that used comparable ERP definitions reported shortened moxidectin and ivermectin ERPs of 35 and 28 days, respectively. It is unclear whether the ERPs of these anthelmintics reduced to such levels are due to the development of AR or some biological factors related to horses, cyathostomin species, and/or the environment. The ERPs for other anthelmintics, such as fenbendazole and pyrantel, were frequently not reported due to established resistance against these drugs. Future research in horses is required to understand the mechanism(s) behind the shortening of ERP for cyathostomins. Based on this systematic review, we propose recommendations for future ERP studies.

Keywords: Anthelmintic resistance; Anthelmintics; Cyathostomins; Egg reappearance period; Horse; Strongylid.

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Conflict of interest statement

Declaration of competing interest The authors are members of the Australian Equine Parasitology Advisory Panel supported by AgriFutures Australia and Boehringer Ingelheim Animal Health Australia. The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Figures

Image 1
Graphical abstract
Fig. 1
Fig. 1
Flow diagram presenting article identification and selection process for the systematic review. This flow diagram is made in accordance with the PRISMA guidelines.
Fig. 2
Fig. 2
Locations of studies evaluating the egg reappearance period (ERP) of equine cyathostomins.
Fig. 3
Fig. 3
Year and anthelmintic(s) assessed by publications evaluating the egg reappearance period (ERP) of small strongyles (n = 54).
See this image and copyright information in PMC

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References

    1. Abbas G., Ghafar A., Hurley J., Bauquier J., Beasley A., Wilkes E.J.A., Jacobson C., El-Hage C., Cudmore L., Carrigan P., Tennent-Brown B., Gauci C.G., Nielsen M.K., Hughes K.J., Beveridge I., Jabbar A. Cyathostomin resistance to moxidectin and combinations of anthelmintics in Australian horses. Parasites Vectors. 2021;14:597. - PMC - PubMed
    1. Anonymous . 2022. Equest®plustape, Overview.https://www.zoetis.com.au/product-class/parasiticide-products/equest-plu...
    1. Baranova M.V., Panova O.A., Polukhina D.N., Panova D.S. Reduction of the nematode egg reappearance period in horses after anthelmintic therapy. Vet. World. 2022;15:1530–1534. - PMC - PubMed
    1. Beasley A.M., Kotze A.C., Allen K., Coleman G.T. A survey of macrocyclic lactone efficacy in Australian cyathostomin populations. Vet. Parasitol. Reg. Stud. Rep. 2017;8:127–132. - PubMed
    1. Bellaw J.L., Krebs K., Reinemeyer C.R., Norris J.K., Scare J.A., Pagano S., Nielsen M.K. Anthelmintic therapy of equine cyathostomin nematodes - larvicidal efficacy, egg reappearance period, and drug resistance. Int. J. Parasitol. 2018;48:97–105. - PubMed

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