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Comment
. 2022 Dec 20;3(12):100837.
doi: 10.1016/j.xcrm.2022.100837.

Advances in co-opting anti-depressant drugs in glioma therapy

Ayush Pant  1 , Michael Lim  2
Affiliations
Comment

Advances in co-opting anti-depressant drugs in glioma therapy

Ayush Pant et al. Cell Rep Med. .

Abstract

A study by Chryplewicz et al. demonstrated the efficacy of combining tricyclic antidepressant imipramine and anti-VEGF therapy in treating genetically engineered glioma models. Dual therapy synergistically improved vascular integrity, increased autophagy, and modulated the myeloid and lymphoid compartments in glioma.

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Conflict of interest statement

Declaration of interests The authors declare no competing interests.

Comment on

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