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. 2023 Jan;23(1):28-30.
doi: 10.1016/S1473-3099(22)00805-2.

Omicron BQ.1 and BQ.1.1 escape neutralisation by omicron subvariant breakthrough infection

Xiao-Lin Jiang  1 , Ka-Li Zhu  2 , Xue-Jun Wang  3 , Guo-Lin Wang  4 , Yi-Ke Li  3 , Xue-Juan He  3 , Wen-Kui Sun  1 , Peng-Xiang Huang  1 , Jin-Zhong Zhang  5 , Hui-Xia Gao  6 , Er-Hei Dai  6 , Mai-Juan Ma  7
Affiliations

Omicron BQ.1 and BQ.1.1 escape neutralisation by omicron subvariant breakthrough infection

Xiao-Lin Jiang et al. Lancet Infect Dis. 2023 Jan.
No abstract available

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Conflict of interest statement

X-LJ, K-LZ, and X-JW contributed equally as joint first authors. E-HD and M-JM contributed equally as joint last authors. We declare no competing interests. We thank all study subjects for their participation in our study. This work was supported by grants from the National Natural Science Foundation of China (82273692, 92169207, 81621005, and 81830101), the Beijing Natural Science Foundation (L202038), and the Key Research and Development Plan of Shandong Province (2021RZA01021).

Figures

Figure
Figure
Neutralisation of omicron subvariants by serum samples from individuals with delta and omicron subvariant breakthrough infections Neutralisation of omicron subvariants, determined by 50% neutralisation titres, by 20 serum samples collected from individuals with delta breakthrough infections (A), 19 serum samples collected from individuals with BA.1 breakthrough infections (B), 15 serum samples collected from individuals with BA.2.2 breakthrough infections (C), 19 serum samples collected from individuals with BA.5.12 breakthrough infections (D), 17 serum samples collected from individuals with BA.2.76 breakthrough infections (E), and 16 serum samples collected from individuals with BF.7 breakthrough infections (F). The horizontal dotted line in all graphs represents a limit of detection of 30, and serum samples with a neutralisation of less than 30 are plotted as 10. The geomatic mean titres and the percentage of individuals with 50% neutralisation titres values above the limit of detection are shown at the bottom of the graph. The fold-change of the geometric mean titre is denoted in brackets. A two-tailed Friedman test with a false discovery rate for multiple comparisons was performed.
Figure
Figure
Neutralisation of omicron subvariants by serum samples from individuals with delta and omicron subvariant breakthrough infections Neutralisation of omicron subvariants, determined by 50% neutralisation titres, by 20 serum samples collected from individuals with delta breakthrough infections (A), 19 serum samples collected from individuals with BA.1 breakthrough infections (B), 15 serum samples collected from individuals with BA.2.2 breakthrough infections (C), 19 serum samples collected from individuals with BA.5.12 breakthrough infections (D), 17 serum samples collected from individuals with BA.2.76 breakthrough infections (E), and 16 serum samples collected from individuals with BF.7 breakthrough infections (F). The horizontal dotted line in all graphs represents a limit of detection of 30, and serum samples with a neutralisation of less than 30 are plotted as 10. The geomatic mean titres and the percentage of individuals with 50% neutralisation titres values above the limit of detection are shown at the bottom of the graph. The fold-change of the geometric mean titre is denoted in brackets. A two-tailed Friedman test with a false discovery rate for multiple comparisons was performed.
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