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. 2022 Dec 22;31(1):74.
doi: 10.1007/s00520-022-07468-7.

Systematic review of caregiver burden, unmet needs and quality-of-life among informal caregivers of patients with pancreatic cancer

Eric Chong  1 , Lisa Crowe  2 , Keno Mentor  2   3 , Sanjay Pandanaboyana  2   3 , Linda Sharp  4
Affiliations

Systematic review of caregiver burden, unmet needs and quality-of-life among informal caregivers of patients with pancreatic cancer

Eric Chong et al. Support Care Cancer. .

Abstract

Purpose: Informal caregivers play an important supportive care role for patients with cancer. This may be especially true for pancreatic cancer which is often diagnosed late, has a poor prognosis and is associated with a significant symptom burden. We systematically reviewed the evidence on caregiver burden, unmet needs and quality-of-life of informal caregivers to patients with pancreatic cancer.

Method: PubMed, Medline, CINAHL and Embase databases were systematically searched on 31 August 2021. Qualitative and quantitative data on informal caregivers' experiences were extracted and coded into themes of burden, unmet needs or quality-of-life with narrative synthesis of the data undertaken.

Results: Nine studies (five qualitative, four quantitative), including 6023 informal caregivers, were included in the review. We categorised data into three key themes: caregiver burden, unmet needs and quality-of-life. Data on caregiver burden was organised into a single subtheme relating to symptom management as a source of burden. Data on unmet needs was organised into three subthemes need for: better clinical communication; support and briefings for caregivers; and help with navigating the health care system. Data on quality-of-life indicate large proportions of informal caregivers experience clinical levels of anxiety (33%) or depression (12%-32%). All five qualitative studies were graded as good quality; three quantitative studies were poor quality, and one was fair quality.

Conclusion: High-quality pancreatic cancer care should consider the impacts of informal caregiving. Prospective longitudinal studies examining multiple dimensions of caregiver burden, needs, and quality-of-life would be valuable at informing supportive care cancer delivery to pancreatic cancer informal caregivers.

Keywords: Caregiver burden; Pancreatic cancer; Quality-of-life; Supportive care; Unmet needs.

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Conflict of interest statement

The authors declare no competing interests.

Figures

Fig. 1
Fig. 1
PRISMA flowchart of literature search
See this image and copyright information in PMC

Comment in

References

    1. Kamisawa T, Wood LD, Itoi T, Takaori K (2016) Pancreatic cancer. The Lancet 388(10039):73–85 - PubMed
    1. Mizrahi JD, Surana R, Valle JW, Shroff RT (2020) Pancreatic cancer. Lancet 395(10242):2008–2020 - PubMed
    1. Khalaf N, El-Serag HB, Abrams HR, Thrift AP (2021) Burden of pancreatic cancer: from epidemiology to practice. Clin Gastroenterol Hepatol 19(5):876–884 - PMC - PubMed
    1. Kleeff J, Korc M, Apte M, La Vecchia C, Johnson CD, Biankin AV et al (2016) Pancreatic cancer. Nat Rev Dis Primers 2(1):1–22 - PubMed
    1. Engebretson A, Matrisian L, Thompson C (2015) Pancreatic cancer: patient and caregiver perceptions on diagnosis, psychological impact, and importance of support. Pancreatology 15(6):701–707 - PubMed

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