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Review
. 2022 Dec 5:13:1079708.
doi: 10.3389/fimmu.2022.1079708. eCollection 2022.

Milestones in acute GVHD pathophysiology

Gerard Socie  1   2   3 , David Michonneau  1   2   3
Affiliations
Review

Milestones in acute GVHD pathophysiology

Gerard Socie et al. Front Immunol. .

Abstract

In the past 65 years, over 25 000 referenced articles have been published on graft-versus-host disease (GVHD). Although this included clinically orientated papers or publications on chronic GVHD, the conservative estimate of scientific publications still contains several thousands of documents on the pathophysiology of acute GVHD. Thus, summarizing what we believe are prominent publications that can be considered milestones in our knowledge of this disease is a challenging and inherently biased task. Here we review from a historical perspective what can be regarded as publications that have made the field move forward. We also included several references of reviews on aspects we could not cover in detail.

Keywords: GvHD; acute; history; milestones; pathophysiology.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

Figure 1
Figure 1
Referenced publications on graft-versus host disease (GVH). The diagram illustrates the number of publications referenced in PubMed as of October 2022. MHC, major histocompatibility complex; GvL, graft-versus-leukemia effect; DCs, Dendritic cells.
See this image and copyright information in PMC

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