Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comment
. 2023;3(1):5.
doi: 10.20517/jca.2022.40. Epub 2023 Jan 1.

The importance of "when" in calorie restriction-induced lifespan extension

Affiliations
Comment

The importance of "when" in calorie restriction-induced lifespan extension

Kristin Eckel-Mahan. J Cardiovasc Aging. 2023.
No abstract available

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest The author declared that there are no conflicts of interest.

Figures

Figure 1.
Figure 1.
Caloric restriction promotes longevity, but preserves circadian robustness and provides maximal lifespan extension when administered during the active phase. (A) Three of the six feeding regimens used to demonstrate the lifespan extension by calorie restriction. Only energy intake at night provided maximal lifespan expansion and maintained circadian robustness. (B) Caloric restriction preserved insulin sensitivity throughout aging, having a protective effect on tissues across the body.

Comment on

References

    1. Durgan DJ, Young ME. The cardiomyocyte circadian clock: emerging roles in health and disease. Circ Res 2010;106:647–58. DOI - DOI - PMC - PubMed
    1. Chaix A, Lin T, Le HD, Chang MW, Panda S. Time-restricted feeding prevents obesity and metabolic syndrome in mice lacking a circadian clock. Cell Metab 2019;29:303–319.e4. DOI - PMC - PubMed
    1. Hatori M, Vollmers C, Zarrinpar A, et al. Time-restricted feeding without reducing caloric intake prevents metabolic diseases in mice fed a high-fat diet. Cell Metab 2012;15:848–60. DOI - PMC - PubMed
    1. Damiola F, Le Minh N, Preitner N, Kornmann B, Fleury-olela F, Schibler U. Restricted feeding uncouples circadian oscillators in peripheral tissues from the central pacemaker in the suprachiasmatic nucleus. Genes Dev 2000;14:2950–61. DOI - PMC - PubMed
    1. Acosta-Rodríguez V, Rijo-Ferreira F, Izumo M, et al. Circadian alignment of early onset caloric restriction promotes longevity in male C57BL/6J mice. Science 2022;376:1192–202. DOI - DOI - PMC - PubMed

LinkOut - more resources