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Review
. 2022 Dec 5:9:1077968.
doi: 10.3389/fmolb.2022.1077968. eCollection 2022.

A review on the role of miR-671 in human disorders

Soudeh Ghafouri-Fard  1 , Arian Askari  2 , Bashdar Mahmud Hussen  3   4 , Mohammed Fatih Rasul  5 , Sevak Hatamian  6 , Mohammad Taheri  7   8 , Arda Kiani  9
Affiliations
Review

A review on the role of miR-671 in human disorders

Soudeh Ghafouri-Fard et al. Front Mol Biosci. .

Abstract

miR-671 is encoded by a gene on 7q36.1 and contributes to the pathogenesis of a variety of disorders, including diverse types of cancers, atherosclerosis, ischemic stroke, liver fibrosis, osteoarthritis, Parkinson's disease, rheumatoid arthritis, acute myocardial infarction and Crohn's disease. In the context of cancer, different studies have revealed opposite roles for this miRNA. In brief, it has been shown to be down-regulated in pancreatic ductal carcinoma, ovarian cancer, gastric cancer, osteosarcoma, esophageal squamous cell carcinoma and myelodysplastic syndromes. Yet, miR-671 has been up-regulated in glioma, colorectal cancer, prostate cancer and hepatocellular carcinoma. Studies in breast, lung and renal cell carcinoma have reported inconsistent results. The current review aims at summarization of the role of miR-671 in these disorders focusing on its target mRNA in each context and dysregulated signaling pathways. We also provide a summary of the role of this miRNA as a prognostic factor in malignancies.

Keywords: biomarker; cancer; expression; mir-671; prognostic.

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Conflict of interest statement

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Figures

FIGURE 1
FIGURE 1
The illustration shows signaling pathways underlying the role of miRNA-671 is as a tumor suppressor miRNA in cancers. miRNA-671 inhibits many signaling pathways and carcinogenic mRNAs, resulting in increased apoptosis while lowering proliferation, migration, and invasion of cancer cells.
FIGURE 2
FIGURE 2
The above illustration shows the roles of miRNA-671, which acts as an oncogene and stimulates cancer growth in several types of cancer. MiRNA-671 can target different tumor suppressor mRNAs and, through inhibition of translation, increase proliferation, migration, and invasion of cancer cells.
FIGURE 3
FIGURE 3
The illustration represents the main functions of miRNA-671 in non-malignant disorders. The level of miRNA-671 expression influences the development of a wide range of disorders by modulation of several signaling pathways.
See this image and copyright information in PMC

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