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. 2023 Aug 1;62(8):2748-2756.
doi: 10.1093/rheumatology/keac706.

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care

Lorraine Watson  1 , John Belcher  1 , Elaine Nicholls  1   2 , Priyanka Chandratre  3 , Milica Blagojevic-Bucknall  1 , Samantha Hider  1   4 , Sarah A Lawton  1 , Christian D Mallen  1   4 , Sara Muller  1 , Keith Rome  5 , Edward Roddy  1   4
Affiliations

Factors associated with change in health-related quality of life in people with gout: a 3-year prospective cohort study in primary care

Lorraine Watson et al. Rheumatology (Oxford). .

Abstract

Objective: To describe factors associated with change in health-related quality of life (HRQOL) in people living with gout in primary care.

Methods: In a UK prospective cohort study, adults with a diagnosis of gout registered with 20 general practices completed the Gout Impact Scale (GIS; scale 0-100), 36-item Short Form Physical Function subscale (PF-10; 0-100) and HAQ Disability Index (HAQ-DI; 0-3) via postal questionnaires at baseline and 6, 12, 24 and 36 months. Linear mixed modelling was used to investigate factors associated with changes in HRQOL over 3 years.

Results: A total of 1184 participants responded at baseline (adjusted response 65.6%); 990 (83.6%) were male, with a mean age of 65.6 years (s.d. 12.5). A total of 818, 721, 696 and 605 responded at 6, 12, 24 and 36 months, respectively. Factors associated with worse disease-specific and generic HRQOL over 3 years were flare frequency (five or more flares; GIS subscales, PF-10), oligo/polyarticular flares (GIS subscales, PF-10, HAQ-DI), worse pain (GIS subscales, PF-10, HAQ-DI), body pain (GIS subscales, PF-10, HAQ-DI) and more severe depression (GIS subscales, PF-10, HAQ-DI) (P ≤ 0.05). More severe anxiety was associated with worse disease-specific HRQOL only (GIS subscales). Older age (PF-10), being female (PF-10, HAQ-DI) and BMI (HAQ-DI) were associated with worse generic HRQOL (P ≤ 0.05).

Conclusion: Gout-specific, comorbid and sociodemographic factors were associated with change in HRQOL over a 3-year period, highlighting people at risk of worse outcomes who could be targeted for interventions.

Keywords: gout; health-related quality of life; primary care; prospective cohort study.

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