Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2023 May;131(5):623-630.
doi: 10.1111/bju.15955. Epub 2023 Jan 6.

Treatment decision regret in long-term survivors after radical prostatectomy: a longitudinal study

Valentin H Meissner  1 , Barbara W Simson  1 , Andreas Dinkel  2 , Stefan Schiele  1 , Donna P Ankerst  3 , Lukas Lunger  1 , Jürgen E Gschwend  1 , Kathleen Herkommer  1
Affiliations

Treatment decision regret in long-term survivors after radical prostatectomy: a longitudinal study

Valentin H Meissner et al. BJU Int. 2023 May.

Abstract

Objectives: To investigate prevalence, course, and predictors of longitudinal decision regret in long-term prostate cancer (PCa) survivors treated by radical prostatectomy (RP).

Patients and methods: A total of 1003 PCa survivors from the multicentre German Familial PCa Database completed questionnaires on average 7 years after RP in 2007 and at follow-up 13 years later in 2020. Patients completed standardised patient-reported outcome measures on decision regret, decision-making, health-related quality of life, and psychosocial factors. Hierarchical multivariable logistic regression was used to assess predictors of longitudinal decision regret.

Results: Decision regret increased significantly over time (9.0% after 6.9 years in 2007 and 12% after 19 years in 2020; P = 0.009). Favourable localised PCa (odds ratio [OR] 1.97, 95% confidence interval [CI] 1.05-3.68), decision regret in 2007 (OR 6.38, 95% CI 3.55-11.47), and a higher depression score (OR 1.37, 95% CI 1.03-1.83) were associated with decision regret in 2020. Shared decision-making (OR 0.55, 95% CI 0.33-0.93) was associated with less decision regret.

Conclusion: The findings of the present study underline the perseverance of decision regret in long-term PCa survivors and the definitive need for involving patients in the decision-making process to mitigate regret over the long term.

Keywords: #PCSM; #ProstateCancer; #uroonc; decision-making; patient-reported outcome measures; prostatectomy; prostatic neoplasms; quality of life; regret.

PubMed Disclaimer

References

    1. Mottet N, van den Bergh RCN, Briers E et al. EAU-EANM-ESTRO-ESUR-SIOG guidelines on prostate Cancer-2020 update. Part 1: Screening, diagnosis, and local treatment with curative intent. Eur Urol 2021; 79: 243-62
    1. Hamdy FC, Donovan JL, Lane JA et al. 10-year outcomes after monitoring, surgery, or radiotherapy for localized prostate cancer. N Engl J Med 2016; 375: 1415-24
    1. Wilt TJ, MacDonald R, Rutks I, Shamliyan TA, Taylor BC, Kane RL. Systematic review: Comparative effectiveness and harms of treatments for clinically localized prostate cancer. Ann Intern Med 2008; 148: 435-48
    1. Morris BB, Farnan L, Song L et al. Treatment decisional regret among men with prostate cancer: Racial differences and influential factors in the North Carolina health access and prostate cancer treatment project (HCaP-NC). Cancer 2015; 121: 2029-35
    1. Hoffman RM, Lo M, Clark JA et al. Treatment decision regret among long-term survivors of localized prostate cancer: Results from the prostate cancer outcomes study. J Clin Oncol 2017; 35: 2306-14

Publication types

LinkOut - more resources