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. 2023 Jul 1;108(7):1940-1944.
doi: 10.3324/haematol.2022.281472.

Kaposi sarcoma herpesvirus viral load as a biomarker for leptomeningeal involvement by primary effusion lymphoma

Kathryn Lurain  1 , Ramya Ramaswami  2 , Vickie Marshall  3 , Elena M Cornejo Castro  3 , Nazzarena Labo  3 , Wendell Miley  3 , Kyle Moore  3 , Romin Roshan  3 , Ralph Mangusan  2 , Elaine S Jaffe  4 , Stefania Pittaluga  4 , Hao-Wei Wang  4 , Mark Roth  4 , Armando C Filie  4 , Thomas S Uldrick  2 , Denise Whitby  3 , Robert Yarchoan  2
Affiliations

Kaposi sarcoma herpesvirus viral load as a biomarker for leptomeningeal involvement by primary effusion lymphoma

Kathryn Lurain et al. Haematologica. .
No abstract available

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Figures

Figure 1.
Figure 1.
Cerebrospinal fluid of patient with leptomeningeal primary effusion lymphoma. Panel (A) shows cytology cerebrospinal fluid (CSF). The white arrow indicates a malignant lymphocyte. Panel (B) shows a paraffin-embedded malignant cell from the same patient’s CSF. The malignant cells are positive for both Kaposi sarcoma herpesvirus by (C) latency nuclear antigen staining (LANA) in brown and for Epstein Barr virus by (D) EBV-encoded small RNA (EBER) staining in dark blue.
Figure 2.
Figure 2.
Receiver operator characteristic curves of the Kaposi sarcoma herpesvirus viral load in the cerebrospinal fluid to detect leptomeningeal involvement in patients with primary effusion lymphoma. (A) First cerebrospinal fluid (CSF) sampling (area under the curve=0.989) and (B) at any cerebrospinal fluid sampling time point (area under the pathology (Table 1). This patient had active MCD and a PBMC-associated KSHV VL of 91,000 copies/106 cells. He was successfully treated for MCD and was followed for several years without development of PEL. At first CSF sampling, the CSF KSHV VL in all patients with any KSHV-associated disease revealed that when using a cut-off of 391 copies/mL, the KSHV VL had a sensitivity of 100% and specificity of 94% to detect CSF-PEL with a positive likelihood ratio of 17 and a negative likelihood ratio of <0.00001.
See this image and copyright information in PMC

References

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