Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2023 Feb;24(2):e13879.
doi: 10.1002/acm2.13879. Epub 2022 Dec 22.

Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles

Elham Mansouri  1 , Asghar Mesbahi  2   3 , Mohammad Saied Hejazi  2 , Soheila Montazersaheb  2 , Vahideh Tarhriz  2 , Tohid Ghasemnejad  2 , Mojtaba Zarei  1
Affiliations
Review

Nanoscopic biodosimetry using plasmid DNA in radiotherapy with metallic nanoparticles

Elham Mansouri et al. J Appl Clin Med Phys. 2023 Feb.

Abstract

Nanoscopic lesions (complex damages), are the most lethal lesions for the cells. As nanoparticles have become increasingly popular in radiation therapy and the importance of analyzing nanoscopic dose enhancement has increased, a reliable tool for nanodosimetry has become indispensable. In this regard, the DNA plasmid is a widely used tool as a nanodosimetry probe in radiobiology and nano-radiosensitization studies. This approach is helpful for unraveling the radiosensitization role of nanoparticles in terms of physical and physicochemical effects and for quantifying radiation-induced biological damage. This review discusses the potential of using plasmid DNA assays for assessing the relative effects of nano-radiosensitizers, which can provide a theoretical basis for the development of nanoscopic biodosimetry and nanoparticle-based radiotherapy.

Keywords: DNA plasmid; biodosimetry; nanoparticle; radiation therapy.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

FIGURE 1
FIGURE 1
Schematic description about NP‐aided radiotherapy
FIGURE 2
FIGURE 2
(a) Response function of absorbed dose‐SSB/DSB for Hadron beams. (b) Response function of absorbed dose‐SSB/DSB for photon beams
See this image and copyright information in PMC

References

    1. Megid WA, Ensenberger MG, Halberg RB, et al. A novel method for biodosimetry. Radiat Environ Biophys. 2007; 6: 147‐154. 10.1007/s00411-006-0072-1 - DOI - PubMed
    1. Macaeva E, Mysara M, De Vos WH, Baatout S, Quintens R. Gene expression‐based biodosimetry for radiological incidents: assessment of dose and time after radiation exposure. Int J Radiat Biol. 2019; 95(1): 64‐75. 10.1080/09553002.2018.1511926 - DOI - PubMed
    1. Kim D, Marchetti F, Chen Z, et al. Nanosensor biodosimetry of mouse blood proteins after exposure to ionizing radiation. Sci Rep. 2013; 3(1):1‐8. - PMC - PubMed
    1. Brun E, Sanche L, Sicard‐Roselli C. Parameters governing gold nanoparticle X‐ray radiosensitization of DNA in solution. Coll. Surf. B, Biointerfaces. 2009; 72: 128‐134. 10.1016/j.colsurfb.2009.03.025 - DOI - PubMed
    1. McMahon S, Hyland WB, Brun E, et al. Energy dependence of gold nanoparticle radiosensitization in plasmid DNA. J Phys Chem C. 2011; 115(41): 20160‐20167. 10.1021/jp206854s - DOI