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. 2022 Nov 29;14(4):519-527.
doi: 10.3390/pediatric14040060.

The Association between SARS-CoV-2 Infection and Diabetic Ketoacidosis in Patients with New-Onset Diabetes: A Retrospective Study from a Diabetic Center in Saudi Arabia

Eman Hurissi  1 , Mohammed Alameer  1 , Fadiyah Ageeli  1 , Maram Allami  1 , Mohammed Alharbi  1 , Hussam Suhail  1 , Hadeel Albeishy  1 , Omar Oraibi  1 , Mohammed Somaili  1 , Abdulrahman Hummadi  2 , Abdulaziz H Alhazmi  1
Affiliations

The Association between SARS-CoV-2 Infection and Diabetic Ketoacidosis in Patients with New-Onset Diabetes: A Retrospective Study from a Diabetic Center in Saudi Arabia

Eman Hurissi et al. Pediatr Rep. .

Abstract

Background: Various reports described new-onset diabetes during or after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in patients with no previous history of diabetes or glucocorticoid use. Further, SARS-CoV-2 could increase the risk of diabetes, including diabetic ketoacidosis (DKA). However, data on the relationship between new-onset diabetes and COVID-19 are still limited in our region. Thus, we aimed in this study to evaluate the association between new-onset diabetes and DKA in patients with COVID-19.

Methods: A retrospective, cross-sectional study was conducted at a diabetic center in Jazan province, Saudi Arabia, between 2020 and 2021. Demographic data, COVID-19 status, and DKA incidence were collected and verified manually from diabetic patients' medical records. Data were analyzed using a t-test and chi-square test.

Results: We included 54 diabetic patients diagnosed during the COVID-19 pandemic, with a median age of 17 years. The majority of patients were females (57.4%). About 38.8% were diagnosed with COVID-19, and 16.6% reported having DKA. About 33.3% of the patients who experienced DKA reported being COVID-19-positive. However, only 6% of patients who denied contracting SARS-CoV-2 developed DKA (p-value = 0.020).

Conclusions: Patients with newly diagnosed diabetes due to COVID-19 seem at a higher risk of developing DKA. Further epidemiological and molecular studies are required for a better understanding of the correlation between DKA in patients with diabetes and COVID-19.

Keywords: COVID-19; DKA; DM; Jazan; Saudi Arabia; diabetes.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Prevalence of newly diagnosed patients with DM during the COVID-19 pandemic (p-value = 0.0001).
See this image and copyright information in PMC

References

    1. Zhu N., Zhang D., Wang W., Li X., Yang B., Song J., Zhao X., Huang B., Shi W., Lu R., et al. A Novel Coronavirus from Patients with Pneumonia in China, 2019. N. Engl. J. Med. 2020;382:727–733. doi: 10.1056/NEJMoa2001017. - DOI - PMC - PubMed
    1. WHO Director-General’s Opening Remarks at the Media Briefing on COVID-19—11 March 2020. [(accessed on 6 September 2022)]; Available online: https://www.who.int/director-general/speeches/detail/who-director-genera....
    1. Cascella M., Rajnik M., Aleem A., Dulebohn S.C., Di Napoli R. StatPearls [Internet] StatPearls Publishing; Treasure Island, FL, USA: 2022. Features, Evaluation, and Treatment of Coronavirus (COVID-19) - PubMed
    1. Wang D., Hu B., Hu C., Zhu F., Liu X., Zhang J., Wang B., Xiang H., Cheng Z., Xiong Y., et al. Clinical Characteristics of 138 Hospitalized Patients with 2019 Novel Coronavirus-Infected Pneumonia in Wuhan, China. JAMA. 2020;323:1061–1069. doi: 10.1001/jama.2020.1585. - DOI - PMC - PubMed
    1. Alraddadi B.M., Watson J.T., Almarashi A., Abedi G.R., Turkistani A., Sadran M., Housa A., Almazroa M.A., Alraihan N., Banjar A., et al. Risk Factors for Primary Middle East Respiratory Syndrome Coronavirus Illness in Humans, Saudi Arabia, 2014. Emerg. Infect. Dis. 2016;22:49–55. doi: 10.3201/eid2201.151340. - DOI - PMC - PubMed

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