Epigenetic clocks, aging, and cancer

Sarah E Johnstone^{1

2

3}, Vadim N Gladyshev^{3

4}, Martin J Aryee^{2

3

5}, Bradley E Bernstein^{2

3

6

7}

Affiliations

¹ Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Pathology, Harvard Medical School, Boston, MA, USA.
³ Broad Institute, Cambridge, MA, USA.
⁴ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
⁶ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
⁷ Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Sarah E Johnstone et al. Science. 2022.

. 2022 Dec 23;378(6626):1276-1277.

doi: 10.1126/science.abn4009. Epub 2022 Dec 22.

Sarah E Johnstone^{1

2

3}, Vadim N Gladyshev^{3

4}, Martin J Aryee^{2

3

5}, Bradley E Bernstein^{2

3

6

7}

¹ Department of Pathology, Dana-Farber Cancer Institute, Boston, MA, USA.
² Department of Pathology, Harvard Medical School, Boston, MA, USA.
³ Broad Institute, Cambridge, MA, USA.
⁴ Division of Genetics, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.
⁵ Department of Data Science, Dana-Farber Cancer Institute, Boston, MA, USA.
⁶ Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, MA, USA.
⁷ Department of Cell Biology, Harvard Medical School, Boston, MA, USA.

Abstract

Global methylation changes in aging cells affect cancer risk and tissue homeostasis.