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. 1987 Jul 3;417(2):261-7.
doi: 10.1016/0378-4347(87)80119-6.

High-performance liquid chromatography of 2-mercaptopropionylglycine and its metabolite 2-mercaptopropionic acid in plasma and urine after treatment with thiopronine

B Kågedal  1 , T Andersson, M Carlsson, T Denneberg, A Hoppe
Affiliations

High-performance liquid chromatography of 2-mercaptopropionylglycine and its metabolite 2-mercaptopropionic acid in plasma and urine after treatment with thiopronine

B Kågedal et al. J Chromatogr. .

Abstract

2-Mercaptopropionic acid has been identified as a normal metabolite of 2-mercaptopropionylglycine (thiopronine) when this drug was given to humans and dogs. A high-performance liquid chromatographic method was developed to resolve the derivatives of these two thiols and thus enable simultaneous determination of the two compounds in plasma and urine.

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