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Comment
. 2023 Dec 7;73(1):208-210.
doi: 10.1136/gutjnl-2022-328556.

Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination

Genelle Rose Lunken  1   2 , Liam Golding  2   3 , Alana Schick  4 , Abdelilah Majdoubi  2 , Pascal M Lavoie  2 , Bruce Andrew Vallance  5   2   4
Affiliations
Comment

Gut microbiome and dietary fibre intake strongly associate with IgG function and maturation following SARS-CoV-2 mRNA vaccination

Genelle Rose Lunken et al. Gut. .
No abstract available

Keywords: COLONIC MICROFLORA; COVID-19; DIETARY FIBRE; IMMUNE RESPONSE; SHORT CHAIN FATTY ACIDS.

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Conflict of interest statement

Competing interests: None declared.

Figures

Figure 1
Figure 1
Impact of the mRNA SARS-CoV-2 BNT162b2 vaccine on gut microbiota composition as well as the gut microbiome and dietary factors that affect BNT162b2 vaccine response. (A) Schematic of the study design and blood and stool sample collection timepoints. (B) A significant reduction in Actinobacteriota (p<0.0001), Anaerostipes (p=0.00161) and Blautia (p=0.00103) and an increase in Lachnoclostridium (p=0.00179) were observed after the first BNT162b2 vaccine. (C) Heat-map depicting several significantly higher (red) or lower (blue) (*p<0.05; Wald test) baseline microbial counts in high (quartile 4) vs low (quartile 1) BTN162b2 vaccine responders across several immune parameters. (D) Several gut microbiota species were significantly positively or negatively associated (p<0.01; Wald test) with higher total relative fractional avidity after the second dose of the BNT162b2 vaccine in a subset of participants (n=15). Refer to online supplemental table S2 for the specific species names and p values. (E) Baseline total branched-chain fatty acid (BCFA) concentrations were negatively correlated with RBD IgG (p=0.02, r=−0.35; Spearman rank) and Spike IgG levels (p=0.017, r=−0.36; Spearman rank), isovaleric acid concentrations were negatively associated with RBD IgG (p=0.015, r=−0.37; Spearman rank) and competitive binding antibody (p=0.026, r=−0.34; Spearman rank), and Spike IgG (p=0.013, r=−0.38; Spearman rank) and competitive binding antibody levels (p=0.034, r=−0.32; Spearman rank), and baseline isobutyric acid concentrations were negatively associated with Spike IgG levels (p=0.047, r=−0.29; Spearman rank). (F) High dietary fibre consumers had a significantly greater change in total relative fractional avidity from the first to second BNT162b2 dose compared with low and moderate dietary fibre consumers (p=0.029; Mann-Whitney). (G) High dietary fibre consumers experienced a reduction in total BCFAs (p=0.164, adjusted t-test), isovaleric (p=0.189, adjusted t-test) and isobutyric acid (p=0.213 adjusted t-test) concentrations (−0.186 to –0.198 and −0.177 mean fold change, respectively) after BNT162b2 vaccination, whereas low dietary fibre consumers experienced an increase in total BCFAs, isovaleric and isobutyric acid concentrations (0.08, 0.08 and 0.08 mean fold change, respectively).
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References

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