Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Editorial
. 2022 Dec 22;12(1):22106.
doi: 10.1038/s41598-022-26725-7.

3D genome organization

Asli Silahtaroglu  1 , Joanna M Bridger  2 , Elissa P Lei  3
Affiliations
Editorial

3D genome organization

Asli Silahtaroglu et al. Sci Rep. .

Abstract

Our genomes are highly organized spatially in three-dimensions (3D). In interphase nuclei, the genome is anchored and regulated by various nuclear scaffolds and structures, including the nuclear lamina at the nuclear edge, and nucleoli located more internally within the nucleoplasm. Recently, great effort has been made to understand the intricacies of 3D genome organization and its relevance to genomic and nuclear function. Over the years, many concepts, mathematical models, visual and biochemical methods, and analysis pipelines have been presented to study various aspects of this organization in a multidisciplinary manner, such as is also reflected within this collection.

PubMed Disclaimer

Conflict of interest statement

The authors declare no competing interests.

References

    1. Cremer T, et al. Chromosome territories, interchromatin domain compartment, and nuclear matrix: An integrated view of the functional nuclear architecture. Crit. Rev. Eukaryot. Gene Exp. 2000;10:179–212. doi: 10.1615/CritRevEukarGeneExpr.v10.i2.60. - DOI - PubMed
    1. Dekker J, Rippe K, Dekker M, Kleckner N. Capturing chromosome conformation. Science. 2002;295(5558):1306–1311. doi: 10.1126/science.1067799. - DOI - PubMed
    1. Lieberman-Aiden E, et al. Comprehensive mapping of long-range interactions reveals folding principles of the human genome. Science. 2009;326(5950):289–293. doi: 10.1126/science.1181369. - DOI - PMC - PubMed
    1. Dixon JR, et al. Topological domains in mammalian genomes identified by analysis of chromatin interactions. Nature. 2012;485(7398):376–380. doi: 10.1038/nature11082. - DOI - PMC - PubMed
    1. Birk UJ. Super-resolution microscopy of chromatin. Genes. 2019;10:493. doi: 10.3390/genes10070493. - DOI - PMC - PubMed

Publication types