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Review
. 2022 Dec 7;10(12):3167.
doi: 10.3390/biomedicines10123167.

Antipsychotics in the Treatment of Children and Adolescents with Anorexia Nervosa: A Systematic Review

Jacopo Pruccoli  1   2 , Luca Bergonzini  1   2 , Angela La Tempa  1   2 , Antonia Parmeggiani  1   2
Affiliations
Review

Antipsychotics in the Treatment of Children and Adolescents with Anorexia Nervosa: A Systematic Review

Jacopo Pruccoli et al. Biomedicines. .

Abstract

Evidence about the use of pharmacologic agents in the treatment of Anorexia Nervosa (AN) is lacking, especially in childhood and adolescence. A systematic scoping review was conducted to outline current literature evidence about the use of antipsychotics in this population. A total of 499 studies were identified with the initial search, and 28 of these studies were selected regarding the use of olanzapine (n = 13), risperidone (n = 4), aripiprazole (n = 3), chlorpromazine (n = 3), pimozide (n = 1) clotiapine (n = 1) and multiple antipsychotics (n = 3) in these patients. Overall, major side effects were reported infrequently; improvements in psychopathology and weight measures have been suggested in the majority of the considered studies. Nonetheless, the lack of RCT or good-quality studies strongly limits the generalizability of results in clinical practice.

Keywords: anorexia nervosa; antipsychotics; children and adolescents; feeding and eating disorders.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
PRISMA diagram.
See this image and copyright information in PMC

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