Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec 7;10(12):3173.
doi: 10.3390/biomedicines10123173.

Allogenic Perinatal Tissue for Musculoskeletal Regenerative Medicine Applications: A Systematic Review

Adarsh Aratikatla  1 , Nicola Maffulli  2   3   4   5 , Hugo C Rodriguez  6 , Manu Gupta  7 , Anish G Potty  8 , Ashim Gupta  8   9   10   11   12
Affiliations
Review

Allogenic Perinatal Tissue for Musculoskeletal Regenerative Medicine Applications: A Systematic Review

Adarsh Aratikatla et al. Biomedicines. .

Abstract

Producing tremendous amounts of stress and financial burden on the global patient population and healthcare systems around the world, most current modalities of treatment for musculoskeletal ailments often do not address the etiopathogenetic causes of these disorders. Regenerative medicine for musculoskeletal disorders relies on orthobiologics derived from either allogenic or autologous sources. Multiple drawbacks are associated with autologous sources, including donor-site morbidity, a dearth of studies, and variability in both patient reported and clinical/functional outcomes. On the other hand, allogenic sources address several of these concerns, and continue to be a suitable source of mesenchymal stem cells (MSCs). This review qualitatively reports both the preclinical and clinical outcomes of publications studying the applications of umbilical cord (-derived Wharton's jelly), amniotic suspension allograft, amniotic membrane, and amniotic fluid in musculoskeletal medicine. A systematic review was conducted utilizing the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines on studies published between January 2010 and October 2022 that used allogeneic perinatal tissues. Further randomized controlled clinical studies are necessary to properly evaluate the safety and efficacy of these tissues in orthopedic surgery.

Keywords: PRISMA; Wharton’s jelly; amniotic fluid; amniotic membrane; amniotic tissue; musculoskeletal injuries; orthopaedics; perinatal tissue; regenerative medicine; systematic review; umbilical cord.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
A PRISMA flow diagram outlining the record identification and selection process.
See this image and copyright information in PMC

References

    1. Musculoskeletal Pain: Types, Causes, Symptoms & Treatment. [(accessed on 9 November 2022)]. Available online: https://my.clevelandclinic.org/health/diseases/14526-musculoskeletal-pain.
    1. Middlesworth M. The Cost of Musculoskeletal Disorders (MSDs) [Infographic] [(accessed on 9 November 2022)]. Available online: https://ergo-plus.com/cost-of-musculoskeletal-disorders-infographic/
    1. Gupta A. Allogenic Amniotic Tissue for Treatment of Knee and Hip Osteoarthritis. Pharmaceuticals. 2022;15:404. doi: 10.3390/ph15040404. - DOI - PMC - PubMed
    1. Gupta A., Maffulli N., Rodriguez H.C., Mistovich R.J., Delfino K., Cady C., Fauser A.-M., Cundiff E.D., Martinez M.A., Potty A.G. Cell-Free Stem Cell-Derived Extract Formulation for Treatment of Knee Osteoarthritis: Study Protocol for a Preliminary Non-Randomized, Open-Label, Multi-Center Feasibility and Safety Study. J. Orthop. Surg. Res. 2021;16:514. doi: 10.1186/s13018-021-02672-3. - DOI - PMC - PubMed
    1. Viscosupplementation Treatment for Knee Arthritis-OrthoInfo-AAOS. [(accessed on 9 November 2022)]. Available online: https://orthoinfo.aaos.org/en/treatment/viscosupplementation-treatment-f....

LinkOut - more resources