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Review
. 2022 Dec 13;11(12):2454.
doi: 10.3390/antiox11122454.

The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease

Virginia Athanassiadou  1 , Stella Plavoukou  1 , Eirini Grapsa  1 , Maria G Detsika  2
Affiliations
Review

The Role of Heme Oxygenase-1 as an Immunomodulator in Kidney Disease

Virginia Athanassiadou et al. Antioxidants (Basel). .

Abstract

The protein heme oxygenase (HO)-1 has been implicated in the regulations of multiple immunological processes. It is well known that kidney injury is affected by immune mechanisms and that various kidney-disease forms may be a result of autoimmune disease. The current study describes in detail the role of HO-1 in kidney disease and provides the most recent observations of the effect of HO-1 on immune pathways and responses both in animal models of immune-mediated disease forms and in patient studies.

Keywords: heme oxygenase; immune injury; kidney.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Schematic representation of the glomerulus. The glomerulus is a cluster of capillaries within the Bowman’s capsule. Three different cell types comprise the glomerulus: endothelial cells, epithelial cells (podocytes) and mesangial cells. Endothelial cells are fenestrated, while mesangial cells and the mesangial matrix support the glomerular capillaries. Podocytes are located on the urinary side of the glomerular basement membrane, and they have long foot processes that wrap around the glomerular capillaries.
Figure 2
Figure 2
HO-1 immunomodulatory effects in glomerular diseases. Schematic representation of the effect of HO-1 in diseases that affect the glomerulus.
See this image and copyright information in PMC

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