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Review
. 2022 Nov 30;12(12):2996.
doi: 10.3390/diagnostics12122996.

N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer

Mingyang Ma  1 , Tong Ye  1 , Jiewei Wang  1 , Haiying Zhao  1 , Shutian Zhang  1 , Peng Li  1 , Guiping Zhao  1
Affiliations
Review

N6-methyladenosine Modification of Noncoding RNAs: Mechanisms and Clinical Applications in Cancer

Mingyang Ma et al. Diagnostics (Basel). .

Abstract

N6-methyladenosine (m6A) modification remains the most pivotal epigenetic modification on RNA. As we know, m6A not only affects physiological processes but is also involved in carcinoma. Noncoding RNAs play an indispensable role in the occurrence and development of carcinoma. However, a large amount of research is focused on mRNA currently. Insufficient research has been done on the relationship between noncoding RNA (ncRNA) methylation and cancer. Therefore, this review aims to introduce the theoretical knowledge of m6A modification in noncoding RNA, discuss its function in tumorigenesis and progression, and ultimately summarize its potential clinical applications.

Keywords: N6-methyladenosine; cancer; noncoding RNA.

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Conflict of interest statement

The authors declare no conflict of interest. The sponsors had no role in the design, execution, interpretation, or writing of the study.

Figures

Figure 1
Figure 1
The interaction between miRNA and its m6A regulators.
Figure 2
Figure 2
The interaction between lncRNA and its m6A regulators.
Figure 3
Figure 3
The interaction between circRNA and its m6A regulators.
See this image and copyright information in PMC

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