Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Nov 30;9(12):1880.
doi: 10.3390/children9121880.

Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes

Sivan Farladansky-Gershnabel  1   2 , Hadar Gluska  1   2 , Nufar Halevi  1   2 , Neta Kotser  1   2 , Maya Sharon-Weiner  1   2 , Hanoch Schreiber  1   2 , Rivka Sukenik-Halevi  2   3 , Yaniv Ebner  2   4 , Shmuel Arnon  2   5 , Ofer Markovitch  1   2
Affiliations

Cleft Lip and/or Cleft Palate: Prenatal Accuracy, Postnatal Course, and Long-Term Outcomes

Sivan Farladansky-Gershnabel et al. Children (Basel). .

Abstract

Orofacial clefts include cleft lip (CL) and cleft palate (CP). This retrospective study assessed the efficacy of prenatal sonographic diagnosis of isolated and non-isolated cases of CL/CP and the postnatal outcomes of these children. Data regarding patients diagnosed and treated in the tertiary orofacial clinic from 2000 to 2020 were retrieved from electronic medical records and telephone-based questionnaires. Isolated CL was found in 7 cases (7.2%), isolated CP in 51 (53%), and combined CL/CP in 38 (39.5%), and 22 cases (23%) were associated with other anomalies. Among 96 cases, 39 (40.6%) were diagnosed prenatally. Isolated CL was diagnosed in 5/7 (71.5%), combined clefts in 29/38 (76.3%), and CP in 7/51 (13.8%). Prenatal chromosomal analysis performed in 32/39 (82%) cases was normal for all. The rate of surgical intervention in the first year of life was 36/38 (94.7%) for combined clefts, 5/7 (71.4%) for CL, and 20/51 (39%) for isolated CP. Most children had speech therapy (23/38 (60.5%), 3/7 (42.8%), and 41/51 (80.3%), respectively) and psychotherapy (6/38 (15.7%), 3/7 (42.8%) and, 15/51 (29.4%), respectively). The accuracy rate of sonographic prenatal diagnosis is low. Our results emphasize the suggested work-up of fetuses with CL and/or CP and improvements to parental counseling, as well as their understanding and compliance regarding post-natal therapeutic plans.

Keywords: anomaly scan; cleft lip; cleft palate; post-natal; prenatal diagnosis; ultrasound diagnosis.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the study group.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Shkoukani M.A., Chen M., Vong A. Cleft Lip—A Comprehensive Review. Front. Pediatr. 2013;1:53. doi: 10.3389/fped.2013.00053. - DOI - PMC - PubMed
    1. Malova J., Braxatorisova T., Luha J., Totka A., Bohmer D. Can we predict orofacial cleft in future pregnancy? Bratisl. Lek. Listy. 2016;117:401–406. doi: 10.4149/BLL_2016_079. - DOI - PubMed
    1. Dar P., Gross S.J. Craniofacial and Neck Anomalies. Clin. Perinatol. 2000;27:813–837. doi: 10.1016/S0095-5108(05)70054-3. - DOI - PubMed
    1. Chmait R., Pretorius D., Moore T., Hull A., James G., Nelson T., Jones M. Prenatal detection of associated anomalies in fetuses diagnosed with cleft lip with or without cleft palate in utero. Ultrasound Obstet. Gynecol. Off. J. Int. Soc. Ultrasound Obstet. Gynecol. 2006;27:173–176. doi: 10.1002/uog.2593. - DOI - PubMed
    1. Reiter R., Brosch S., Lüdeke M., Fischbein E., Rinckleb A., Haase S., Schwandt A., Pickhard A., Maier C., Högel J., et al. Do Orofacial Clefts Represent Different Genetic Entities? Cleft Palate-Craniofacial J. 2015;52:115–120. doi: 10.1597/13-016. - DOI - PubMed

LinkOut - more resources