Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2022 Dec 9;9(12):1938.
doi: 10.3390/children9121938.

Brain-Directed Care: Why Neuroscience Principles Direct PICU Management beyond the ABCs

Affiliations
Review

Brain-Directed Care: Why Neuroscience Principles Direct PICU Management beyond the ABCs

Debbie A Long et al. Children (Basel). .

Abstract

Major advances in pediatric intensive care (PICU) have led to increased child survival. However, the long-term outcomes among these children following PICU discharge are a concern. Most children admitted to PICU are under five years of age, and the stressors of critical illness and necessary interventions can affect their ability to meet crucial developmental milestones. Understanding the neuroscience of brain development and vulnerability can inform PICU clinicians of new ways to enhance and support the care of these most vulnerable children and families. This review paper first explores the evidence-based neuroscience principles of brain development and vulnerability and the impact of illness and care on children's brains and ultimately wellbeing. Implications for clinical practice and training are further discussed to help optimize brain health in children who are experiencing and surviving a critical illness or injury.

Keywords: child development; critical care; neuroscience; pediatrics; trauma informed care.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Impact of Stressors on Biological Systems.

References

    1. Tierney A.L., Nelson C.A., III Brain development and the role of experience in the early years. Zero Three. 2009;30:9. - PMC - PubMed
    1. Thompson R.A. Stress and child development. Future Child. 2014;24:41–59. doi: 10.1353/foc.2014.0004. - DOI - PubMed
    1. Johnston M.V. Plasticity in the developing brain: Implications for rehabilitation. Dev. Disabil. Res. Rev. 2009;15:94–101. doi: 10.1002/ddrr.64. - DOI - PubMed
    1. Fox S.E., Levitt P., Nelson C.A., III How the timing and quality of early experiences influence the development of brain architecture. Child Dev. 2010;81:28–40. doi: 10.1111/j.1467-8624.2009.01380.x. - DOI - PMC - PubMed
    1. Hensch T.K., Bilimoria P.M. Cerebrum: The Dana Forum on Brain Science. Dana Foundation; New York, NY, USA: 2012. Re-opening windows: Manipulating critical periods for brain development. - PMC - PubMed

LinkOut - more resources