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. 2022 Dec 6;10(12):2460.
doi: 10.3390/healthcare10122460.

Prescription Opioid Use among Patients with Chronic Noncancer Pain before and after the COVID-19 Outbreak in Taiwan: A Multicenter Prospective Observational Study

Jia-Lin Chen  1 , Shung-Tai Ho  1   2 , Wei-Zen Sun  3   4 , Yu-Chuan Tsai  5 , Kuang-I Cheng  2 , Yen-Chin Liu  2   6   7 , Yi-Jer Hsieh  8 , Yeong-Ray Wen  9 , Po-Kai Wang  10 , Chun-Sung Sung  11 , Chun-Chang Yeh  1 , Tso-Chou Lin  1
Affiliations

Prescription Opioid Use among Patients with Chronic Noncancer Pain before and after the COVID-19 Outbreak in Taiwan: A Multicenter Prospective Observational Study

Jia-Lin Chen et al. Healthcare (Basel). .

Abstract

Background: The COVID-19 outbreak disrupted medical access for patients receiving chronic opioid therapy. This study investigated their prescription opioid dosages before and after the 2020 outbreak in Taiwan.

Methods: A prospective questionnaire survey was conducted among registered outpatients receiving long-term opioids before July 2019 in Taiwan. The questionnaire included items from the Taiwanese Brief Pain Inventory and quality of life assessment. Follow-up surveys in outpatient departments through October 2020 were conducted to collect opioid prescription data.

Results: After a mean of 531 days, the questionnaire responses of 103 of the initial 117 respondents were reviewed. Daily opioid doses decreased for 31 respondents (30.1%), remained roughly equivalent (defined as ±2.5%) for 27 (26.2%), and increased for 45 (43.7%) after the first wave of the pandemic. The use of strong opioids and nonopioid medications did not significantly differ among the three groups, but less fentanyl patch use was noted in the decreased-dose group after the outbreak. More than 70% of the patients received daily high-dose opioids (≥90 morphine milligram equivalents); moreover, 60% reported constipation. No deaths due to opioid overdose occurred during the study period.

Conclusions: The COVID-19 outbreak in 2020 did not interrupt access to long-term opioid prescriptions for most registered patients with chronic pain in Taiwan. Less fentanyl patch use was observed in participants whose opioid dose was tapering.

Keywords: COVID-19; chronic pain; noncancer; opioid; prescription.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

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Figure 1
Participant enrollment flowchart.
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References

    1. Kahan M., Mailis-Gagnon A., Wilson L., Srivastava A. Canadian guideline for safe and effective use of opioids for chronic noncancer pain: Clinical summary for family physicians. Part 1: General population. Can. Fam. Physician. 2011;57:1257–1266. - PMC - PubMed
    1. Dowell D., Haegerich T.M., Chou R. CDC guideline for prescribing opioids for chronic pain—United States, 2016. JAMA. 2016;315:1624–1645. doi: 10.1001/jama.2016.1464. - DOI - PMC - PubMed
    1. Wilson N., Kariisa M., Seth P., Smith H.T., Davis N.L. Drug and opioid-involved overdose deaths—United States, 2017–2018. MMWR Morb. Mortal. Wkly. Rep. 2020;69:290–297. doi: 10.15585/mmwr.mm6911a4. - DOI - PMC - PubMed
    1. National Institute on Drug Abuse Overdose Death Rates, 1999–2020. [(accessed on 15 July 2022)]; Post on 20 January 2022. Available online: https://nida.nih.gov/drug-topics/trends-statistics/overdose-death-rates.
    1. The Draft 2022 CDC Clinical Practice Guideline for Prescribing Opioids Was Posted for a 60-Day Public Comment Period (from 10 February 2022 to 11 April 2022) [(accessed on 15 July 2022)]; Available online: https://www.cdc.gov/opioids/guideline-update/index.html.

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