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. 2022 Dec 9;19(24):16549.
doi: 10.3390/ijerph192416549.

The Microbiome-Gut-Brain Axis and Dementia: A Bibliometric Analysis

He-Li Sun  1   2 , Yuan Feng  3   4 , Qinge Zhang  3   4 , Jia-Xin Li  2 , Yue-Ying Wang  2 , Zhaohui Su  5 , Teris Cheung  6 , Todd Jackson  7 , Sha Sha  3   4 , Yu-Tao Xiang  1   2
Affiliations

The Microbiome-Gut-Brain Axis and Dementia: A Bibliometric Analysis

He-Li Sun et al. Int J Environ Res Public Health. .

Abstract

Background: Associations between the microbiome-gut-brain axis and dementia have attracted considerable attention in research literature. This study examined the microbiome-gut-brain axis and dementia-related research from a bibliometric perspective.

Methods: A search for original research and review articles on the microbiome-gut-brain axis and dementia was conducted in the Web of Science Core Collection (WOSCC) database. The R package "bibliometrix" was used to collect information on countries, institutions, authors, journals, and keywords. VOSviewer software was used to visualize the co-occurrence network of keywords.

Results: Overall, 494 articles met the study inclusion criteria, with an average of 29.64 citations per article. Corresponding authors of published articles were mainly from China, the United States and Italy. Zhejiang University in China and Kyung Hee University in Korea were the most active institutions, while the Journal of Alzheimer's Disease and Nutrients published the most articles in this field. Expected main search terms, "Parkinson disease" and "chain fatty-acids" were high-frequency keywords that indicate current and future research directions in this field.

Conclusions: This bibliometric study helped researchers to identify the key topics and trends in the microbiome-gut-brain axis and dementia-related research. High-frequency keywords identified in this study reflect current trends and possible future directions in this field related to methodologies, mechanisms and populations of interest.

Keywords: Alzheimer’s disease; bibliometrics; brain-gut axis; dementia; hotspots.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flowchart of data selection and analysis.
Figure 2
Figure 2
Year-wise distribution of the documents between 2002–2021.
Figure 3
Figure 3
Top 15 contributing countries on microbiome–gut–brain axis and dementia-related research. Notes: TC: Total number of citations; AAC: Average Article Citations.
Figure 4
Figure 4
International collaboration analysis and the top 20 collaborations between countries.
Figure 5
Figure 5
Top 9 contributing institutions and production over time on microbiome–gut–brain axis and dementia-related research.
Figure 6
Figure 6
Co-occurrence analysis of author keywords and top 10 keywords on COVID-19 and sleep related research. ((A): the most frequently used keywords. (B): Co-occurrence network analysis of author keywords. (C): Co-occurrence overlay analysis of author keywords).
See this image and copyright information in PMC

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