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. 2022 Dec 14;19(24):16754.
doi: 10.3390/ijerph192416754.

Clinical Features and Management of Umbilical Endometriosis: A 30 Years' Monocentric Retrospective Study

Dhouha Dridi  1 , Laura Buggio  1 , Agnese Donati  2 , Francesca Giola  2 , Caterina Lazzari  2 , Massimiliano Brambilla  3 , Francesca Chiaffarino  1 , Giussy Barbara  1   2
Affiliations

Clinical Features and Management of Umbilical Endometriosis: A 30 Years' Monocentric Retrospective Study

Dhouha Dridi et al. Int J Environ Res Public Health. .

Abstract

Introduction: Umbilical endometriosis (UE) is defined as the presence of endometrial-like tissue within the umbilicus and represents around 0.5-1% of all cases of endometriosis. UE is classified into primary or secondary UE. In this retrospective study, we aimed to assess symptoms, signs, recurrence rate of treated lesions, psychological wellbeing and health-related quality of life in women with UE.

Material and methods: We retrospectively reviewed all cases of women diagnosed with UE in the period 1990-2021 in our center. Post-operative recurrence of UE was considered as the reappearance of the umbilical endometriotic lesion, or as the recurrence of local symptoms in the absence of a well-defined anatomical recurrence of the umbilical lesion. Moreover, participants were invited to fill in standardized questionnaires on their health conditions.

Results: A total of 55 women with histologically proven UE were assessed in our center during the study period. At time of diagnosis, local catamenial pain and swelling were reported by 51% and 53.2% of women, respectively. A total of 46.8% of women reported catamenial umbilical bleeding. Concomitant non-umbilical endometriosis was identified in 66% of cases. As regards the treatment of UE, 83.6% of women underwent an en-bloc excision with histological confirmation of UE. During the follow-up period, 37 women (67.3%) agreed to undergo a re-evaluation. Recurrence of either umbilical symptoms, or umbilical nodule, was observed in 27% of patients, 11% of which did not receive post-operative hormonal therapy. Specifically, a recurrence of the umbilical endometriotic lesion was observed only in two women. Among the 37 women which we were able to contact for follow-up, 83.8% were satisfied with the treatment they had received.

Conclusions: The high rate of patient satisfaction confirmed that surgical excision should be considered the gold standard treatment for umbilical endometriosis. Future studies should investigate the role of post-operative hormonal therapy, particularly in reducing the risk of symptom recurrence.

Keywords: endometriosis; pain; surgery; treatment; umbilical endometriosis.

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Conflict of interest statement

The authors report no conflict of interest.

Figures

Figure 1
Figure 1
Umbilical endometriosis nodule.
Figure 2
Figure 2
Cumulative incidence probability of recurrence rate after surgical treatment of umbilical endometriosis.
See this image and copyright information in PMC

References

    1. Andres M.P., Arcoverde F.V.L., Souza C.C.C., Fernandes L.F.C., Abrao M.S., Kho R.M. Extrapelvic endometriosis: A systematic review. J. Minim. Invasive Gynecol. 2020;27:373–389. doi: 10.1016/j.jmig.2019.10.004. - DOI - PubMed
    1. Dubreuil A., Dompmartin A., Barjot P., Louvet S., Leroy D. Umbilical metastasis or Sister Mary Joseph’s nodule. Int. J. Dermatol. 1998;37:7–13. doi: 10.1046/j.1365-4362.1998.00326.x. - DOI - PubMed
    1. Markham S.M., Carpenter S.E., Rock J.A. Extrapelvic endometriosis. Obstet. Gynecol. Clin. N. Am. 1989;16:193–219. doi: 10.1016/S0889-8545(21)00147-9. - DOI - PubMed
    1. Michowitz M., Baratz M., Stavorovsky M. Endometriosis of the umbilicus. Dermatologica. 1983;167:326–330. doi: 10.1159/000249810. - DOI - PubMed
    1. Victory R., Diamond M.P., Johns D.A. Villar’s nodule: A case report and systematic literature review of endometriosis externa of the umbilicus. J. Minim. Invasive Gynecol. 2007;14:23–32. doi: 10.1016/j.jmig.2006.07.014. - DOI - PubMed

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