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. 2022 Dec 17;23(24):16116.
doi: 10.3390/ijms232416116.

Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases

Zhan Wang  1 , Junyi Ren  1 , Jinxiu Du  1 , Huan Wang  1 , Jia Liu  1 , Guiling Wang  1
Affiliations

Niclosamide as a Promising Therapeutic Player in Human Cancer and Other Diseases

Zhan Wang et al. Int J Mol Sci. .

Abstract

Niclosamide is an FDA-approved anthelmintic drug for the treatment of parasitic infections. However, over the past few years, increasing evidence has shown that niclosamide could treat diseases beyond parasitic diseases, which include metabolic diseases, immune system diseases, bacterial and viral infections, asthma, arterial constriction, myopia, and cancer. Therefore, we systematically reviewed the pharmacological activities and therapeutic prospects of niclosamide in human disease and cancer and summarized the related molecular mechanisms and signaling pathways, indicating that niclosamide is a promising therapeutic player in various human diseases, including cancer.

Keywords: FDA-approved drug; cancer; disease; niclosamide; pharmacological activity; therapeutic prospect.

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Conflict of interest statement

No conflict of interest exists in the submission of this manuscript, and this manuscript was approved by all authors for publication. The described work was original research that has been published previously and is not under consideration for publication elsewhere, in whole or in part.

Figures

Figure 1
Figure 1
The structure of the two main salt forms of NIC: NEN and NPP.
Figure 2
Figure 2
The multifaceted pharmacological activities of NIC in human disease and cancer.
Figure 3
Figure 3
The anti-tumor activity and mechanism of NIC.
See this image and copyright information in PMC

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