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. 2022 Dec 8;11(24):7302.
doi: 10.3390/jcm11247302.

Knee Osteoarthritis in Relation to the Risk Factors of the Metabolic Syndrome Components and Environment of Origin

Nicoleta Bianca Tudorachi  1 , Tiberiu Totu  2 , Iuliana Eva  3 , Bogdan Bărbieru  4 , Eugenia Eftimie Totu  5 , Adrian Fifere  6 , Tudor Pinteală  7 , Paul-Dan Sîrbu  7 , Valeriu Ardeleanu  1
Affiliations

Knee Osteoarthritis in Relation to the Risk Factors of the Metabolic Syndrome Components and Environment of Origin

Nicoleta Bianca Tudorachi et al. J Clin Med. .

Abstract

Background: Knee osteoarthritis (KOA) is a chronic degenerative pathology that is associated with multiple risk factors such as age, sex, obesity, or metabolic syndrome (MetS). The present clinical trial aimed to investigate the influence of the environment of origin, body mass index (BMI), and MetS parameters on the KOA differentiated degrees. Methods: 85 patients were admitted for the clinical study. The KOA presence was investigated using X-rays analysis. The Kellgren−Lawrence classification (KL) of the KOA severity and the MetS characteristic parameters using freshly collected blood were performed for each patient. All data collected were used for ANOVA statistic interpretation. Results: The total cholesterol and glycemia were found to be statistically significant (p < 0.028, and p < 0.03, respectively), with a high level in patients with severe KOA compared to healthy ones. Patients from rural regions are 5.18 times more prone to develop severe KOA when compared to ones from urban areas. Conclusions: The results of the statistical analysis confirmed the correlation between the incidence and severity of KOA and the influence of increased values of BMI, glycemia, triglycerides, and total cholesterol. The investigations revealed a statistically significant influence of the environment of origin on the KOA degree of the patients.

Keywords: diabetes mellitus; dyslipidemia; environment of origin; knee osteoarthritis; metabolic syndrome.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
KL classification and illustration of KOA severity, SMUIS X-Ray collection of the clinical study (real cases). (a) KL grade I—doubtful narrowing of the joint space and possible osteophytes; (b) KL grade II—definite osteophytes and possible narrowing of joint space; (c) KL grade III—definite narrowing of the joint space, significant osteophytosis, and possible bone deformities; (d) KL grade IV—marked joint space narrowing accompanied by deformities, bone sclerosis, and large osteophytes.
Figure 1
Figure 1
KL classification and illustration of KOA severity, SMUIS X-Ray collection of the clinical study (real cases). (a) KL grade I—doubtful narrowing of the joint space and possible osteophytes; (b) KL grade II—definite osteophytes and possible narrowing of joint space; (c) KL grade III—definite narrowing of the joint space, significant osteophytosis, and possible bone deformities; (d) KL grade IV—marked joint space narrowing accompanied by deformities, bone sclerosis, and large osteophytes.
Figure 2
Figure 2
Correlation of explanatory variables.
Figure 3
Figure 3
(a) Age distribution stratified by KOA severity with the associated ANOVA test p-value. (b) BMI distribution stratified by KOA severity with the associated ANOVA test p-value.
Figure 4
Figure 4
Distribution of patients’ MetS parameters values function of KOA severity with the associated ANOVA p-values (a) HDL distribution, (b) LDL distribution, (c) total cholesterol distribution, (d) triglycerides distribution, (e) glycemia distribution.
Figure 5
Figure 5
The influence of glycemia on KOA severity stratified by the environment of origin.
See this image and copyright information in PMC

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