Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 8;11(24):7300.
doi: 10.3390/jcm11247300.

The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles

Ling Huang  1   2 , Sunxing Huang  1 , Yangxing Wen  1 , Xiubing Zhang  1 , Xiaokun Hu  1 , Rihan Wu  1 , Minghui Chen  1 , Canquan Zhou  1
Affiliations

The Impact of Late Follicular Phase Progesterone Elevation on Cumulative Live Birth Rate and Embryo Quality in 4072 Freeze-All Cycles

Ling Huang et al. J Clin Med. .

Abstract

Late follicular phase progesterone elevation during in vitro fertilization impedes embryo implantation. It is unclear whether late follicular phase progesterone elevation still has a negative effect on cumulative live births and embryo quality when a freeze-all strategy is adopted. Data from a total of 4072 patients were reviewed. All patients used the freeze-all strategy. Multivariate regression analyses were used to assess the association of progesterone levels with both cumulative live birth and embryo quality. There was no significant difference in the cumulative live birth rate between the groups with progesterone level <1.5 ng/mL and ≥1.5 ng/mL. The progesterone level was not associated with cumulative live birth and embryo quality.

Keywords: cumulative live birth rate; embryo quality; freeze-all strategy; ovarian stimulation; progesterone level.

PubMed Disclaimer

Conflict of interest statement

The authors have no conflict of interest to disclose.

Figures

Figure 1
Figure 1
Flowchart showing the procedures used in selecting the studied patients.
See this image and copyright information in PMC

References

    1. Esteves S.C., Khastgir G., Shah J., Murdia K., Gupta S.M., Rao D.G., Dash S., Ingale K., Patil M., Moideen K., et al. Association Between Progesterone Elevation on the Day of Human Chronic Gonadotropin Trigger and Pregnancy Outcomes After Fresh Embryo Transfer in In Vitro Fertilization/Intracytoplasmic Sperm Injection Cycles. Front. Endocrinol. 2018;9:201. doi: 10.3389/fendo.2018.00201. - DOI - PMC - PubMed
    1. Yding Andersen C., Bungum L., Nyboe Andersen A., Humaidan P. Preovulatory progesterone concentration associates significantly to follicle number and LH concentration but not to pregnancy rate. Reprod. Biomed. Online. 2011;23:187–195. doi: 10.1016/j.rbmo.2011.04.003. - DOI - PubMed
    1. Oktem O., Akin N., Bildik G., Yakin K., Alper E., Balaban B., Urman B. FSH Stimulation promotes progesterone synthesis and output from human granulosa cells without luteinization. Hum. Reprod. 2017;32:643–652. doi: 10.1093/humrep/dex010. - DOI - PubMed
    1. Racca A., De Munck N., Santos-Ribeiro S., Drakopoulos P., Errazuriz J., Galvao A., Popovic B., Mackens S., De Vos M., Verheyen G., et al. Do we need to measure progesterone in oocyte donation cycles? A retrospective analysis evaluating cumulative live birth rates and embryo quality. Hum. Reprod. 2020;35:167–174. doi: 10.1093/humrep/dez238. - DOI - PubMed
    1. Healy M.W., Yamasaki M., Patounakis G., Richter K.S., Devine K., DeCherney A.H., Hill M.J. The slow growing embryo and premature progesterone elevation: Compounding factors for embryo-endometrial asynchrony. Hum. Reprod. 2017;32:362–367. doi: 10.1093/humrep/dew296. - DOI - PMC - PubMed

LinkOut - more resources