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Review
. 2022 Dec 6;12(12):2038.
doi: 10.3390/life12122038.

Helicobacter Pylori: A Review of Current Treatment Options in Clinical Practice

Logan T Roberts  1 , Peter P Issa  1 , Evan S Sinnathamby  1 , Mallory Granier  1 , Holly Mayeux  1 , Treniece N Eubanks  2 , Kevin Malone  3 , Shahab Ahmadzadeh  2 , Elyse M Cornett  2 , Sahar Shekoohi  2 , Alan D Kaye  4
Affiliations
Review

Helicobacter Pylori: A Review of Current Treatment Options in Clinical Practice

Logan T Roberts et al. Life (Basel). .

Abstract

Background: When prescribing antibiotics, infection eradication rates, local resistance rates, and cost should be among the most essential considerations. Helicobacter pylori is among the most common infections worldwide, and it can lead to burdensome sequela for the patient and the healthcare system, without appropriate treatment. Due to constantly fluctuating resistance rates, regimens must be constantly assessed to ensure effectiveness.

Methods: This was a narrative review. The sources for this review are as follows: searching on PubMed, Google Scholar, Medline, and ScienceDirect; using keywords: Helicobacter pylori, Treatment Options, Clinical Practice.

Results: Multiple antibiotics are prescribed as part of the regimen to thwart high resistance rates. This can lead to unwanted adverse reactions and adherence issues, due to the amount and timing of medication administration, which also may contribute to resistance. Single-capsule combination capsules have reached the market to ease this concern, but brand-only may be problematic for patient affordability. Due to the previously mentioned factors, effectiveness and affordability must be equally considered.

Conclusions: This review will utilize guidelines to discuss current treatment options and give cost considerations to elicit the most effective regimen for the patient.

Keywords: Helicobacter pylori; clinical practice; treatment options.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Drawing of H. pylori-induced gastritis. Should H. pylori infection go untreated, severe complications such as gastritis, PUD, MALT lymphoma, stomach or esophageal cancer, and potentially idiopathic thrombocytopenic purpura may result.
Figure 2
Figure 2
H. pylori bacterium, colored transmission electron micrograph (TEM). Image paid for by authors; stock photo from Canva.
Figure 3
Figure 3
Stained microscopic image of stomach biopsy; reactive epithelium from H. pylori-induced gastritis. Image paid for by authors; stock photo from Canva.
Figure 4
Figure 4
H. pylori can only thrive in a microaerobic environment with a nutrient-rich medium and serum. Image paid for by authors; stock photo from Canva.
See this image and copyright information in PMC

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