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Case Reports
. 2022 Dec 9;12(12):2067.
doi: 10.3390/life12122067.

Primary Cutaneous B-Cell Lymphoma Co-Existing with Mycosis Fungoides-A Case Report and Overview of the Literature

Doriana Sorina Chilom  1 , Simona Sorina Farcaș  2 , Nicoleta Ioana Andreescu  2
Affiliations
Case Reports

Primary Cutaneous B-Cell Lymphoma Co-Existing with Mycosis Fungoides-A Case Report and Overview of the Literature

Doriana Sorina Chilom et al. Life (Basel). .

Abstract

The existence of two sequential lymphomas, one localized and one systemic, either both with B or T lymphocytes, or one with B cells and one with T cells, with the same patient, is a known possibility. The second lymphoma is often induced by immunodepression or by the initial treatment. However, the existence of two cutaneous lymphomas with different cell lines, without systemic involvement, represents an uncommon situation. In this report, we describe the case of a 37-year-old man with an initial diagnosis of PMZBCL that over 10 months also developed a MF patch/plaque on the left leg.

Keywords: B-cell lymphoma; Mycosis Fungoides; composite lymphomas; primary cutaneous lymphoma.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Primary marginal zone B-cell Lymphoma on the antero-lateral part of the lower left leg; purple–red plaque with shiny surface.
Figure 2
Figure 2
Primary marginal zone B-cell Lymphoma, Hematoxylin & Eosin stain, Ob ×20.
Figure 3
Figure 3
(a): Primary marginal zone B-cell Lymphoma, CD20 Ob ×20. (b): Primary marginal zone B-cell Lymphoma, Bcl-2, Ob ×20.
Figure 3
Figure 3
(a): Primary marginal zone B-cell Lymphoma, CD20 Ob ×20. (b): Primary marginal zone B-cell Lymphoma, Bcl-2, Ob ×20.
Figure 4
Figure 4
Mycosis Fungoides plaque at the right inguinal fold; oval erythematous and indurated plaque, with a fine scales surface.
Figure 5
Figure 5
Mycosis Fungoides, Hematoxylin & Eosin stain, Ob ×20.
Figure 6
Figure 6
(a): Mycosis Fungoides, CD3, Ob ×20. (b): Mycosis Fungoides, CD4, Ob ×20.
Figure 6
Figure 6
(a): Mycosis Fungoides, CD3, Ob ×20. (b): Mycosis Fungoides, CD4, Ob ×20.
See this image and copyright information in PMC

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