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. 2022 Dec 13;12(12):2092.
doi: 10.3390/life12122092.

Baseline Ang-2 Serum Levels as a Predictive Factor for Survival in NSCLC and SCLC

Asimina Nikolakopoulou  1 , Dimitris Tsakogiannis  2 , Flora Zagouri  3 , Eleni Zografos  3 , Lamprini Tzioga  2 , Grigorios Stratakos  1 , Nikolaos Koulouris  1 , Konstantinos Syrigos  4 , Garyfalia Bletsa  2
Affiliations

Baseline Ang-2 Serum Levels as a Predictive Factor for Survival in NSCLC and SCLC

Asimina Nikolakopoulou et al. Life (Basel). .

Abstract

Angiopoietin-2 (Ang-2) has been implicated in the development of several types of cancer, including lung malignancy. In the present study, we examined the impact of Ang-2 serum concentration on the development, dissemination, and 5-year overall survival of NSCLC and SCLC. A total of 99 patients with lung cancer were tested. The OS of NSCLC and SCLC patients was estimated using Kaplan−Meier curves and compared through log-rank test. The median serum level of Ang-2 at baseline in both NSCLC and SCLC patients was significantly higher than that of controls (p < 0.0001). The Ang-2 serum concentration was not related to metastasis, neither in NSCLC nor in SCLC cases. The OS was found to be significantly shorter for stage IIIβ NSCLC patients with a high baseline Ang-2 serum concentration (p = 0.012), while Cox regression analysis showed that Ang-2 is a significant independent factor for poor prognosis for stage IIIβ NSCLC (hazard ratio = 2.97, 95% CI: 1.05−8.40, p = 0.04). The concentration of Ang-2 has no impact on the prognosis of SCLC. Ang-2 could be considered as a significant molecular marker that enables the prediction of NSCLC and SCLC development, and is involved in the poor prognosis of stage IIIβ NSCLC.

Keywords: Ang-2; NSCLC; SCLC; angiopoietins; lung cancer; prognostic factor.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Ang-2 serum levels of healthy controls compared with the Ang-2 serum levels of patients with lung cancer.
Figure 2
Figure 2
Kaplan–Meier curve for overall survival grouped by baseline serum Ang-2 levels. (A) Overall survival for stage ΙΙΙβ lung cancer patients with high or low serum Ang-2 at baseline. (B) Overall survival for stage IV lung cancer patients with high or low serum Ang-2 at baseline.
Figure 3
Figure 3
Kaplan–Meier curve for overall survival grouped by baseline serum Ang-2 levels. (A) Overall survival for stage ΙΙΙβ NSCLC patients with high or low serum Ang-2 at baseline. (B) Overall survival for stage IV NSCLC patients with high or low serum Ang-2 at baseline.
Figure 4
Figure 4
Kaplan–Meier curve for overall survival grouped by baseline serum Ang-2 levels. (A) Overall survival for stage ΙΙΙβ SCLC patients with high or low serum Ang-2 at baseline. (B) Overall survival for stage IV SCLC patients with high or low serum Ang-2 at baseline.
Figure 5
Figure 5
Ang-2 serum levels of patients at the third cycle of chemotherapy. (A) Ang-2 serum levels of NSCLC patients who received PBC in combination with anti-VEGF before treatment and after the third cycle of chemotherapy. (B) Ang-2 serum levels of SCLC patients who received PBC before treatment and after the third cycle of chemotherapy.
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