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Review
. 2022 Dec 1;10(12):2388.
doi: 10.3390/microorganisms10122388.

The Optimal Management of Neisseria gonorrhoeae Infections

Ramona Gabriela Ursu  1 , Ionut Luchian  2 , Costin Damian  1 , Elena Porumb-Andrese  3 , Roxana Gabriela Cobzaru  1 , Giorgio Nichitean  4 , Carmen Ripa  1 , Diana Costin  1 , Darius Sandu  4 , Ioana-Maria Andrioaie  1 , Luminita Smaranda Iancu  1
Affiliations
Review

The Optimal Management of Neisseria gonorrhoeae Infections

Ramona Gabriela Ursu et al. Microorganisms. .

Abstract

Neisseria gonorrhoeae is one of the most frequent etiologic agents of STDs (sexually transmitted diseases). Untreated asymptomatic gonococcal infection in women can lead to spreading of the infection in the sexually active population and could lead to late consequences, such as sterility or ectopic pregnancies. One important issue about N. gonorrhoeae is its increasing resistance to antibiotics. This paper summarized the newest molecular antimicrobial resistance (AMR) detection assays for Neisseria gonorrhoeae connected with the latest therapeutic antimicrobials and gonococcal vaccine candidates. The assays used to detect AMR varied from the classical minimal inhibitory concentration (MIC) detection to whole-genome sequencing. New drugs against multi drug resistant (MDR) N. gonorrhoeae have been proposed and were evaluated in vivo and in vitro as being efficient in decreasing the N. gonorrhoeae burden. In addition, anti-N. gonorrhoeae vaccine candidates are being researched, which have been assessed by multiple techniques. With the efforts of many researchers who are studying the detection of antimicrobial resistance in this bacterium and identifying new drugs and new vaccine candidates against it, there is hope in reducing the gonorrhea burden worldwide.

Keywords: AMR detection assay; NG vaccine candidate; gonococcal infections; new drugs.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Diagram of analyzed studies.
Figure 2
Figure 2
Schematic representation of the new therapeutical drugs against N. gonorrhoeae [19,20,21,22,23].
See this image and copyright information in PMC

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