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Review
. 2022 Dec 9;10(12):2436.
doi: 10.3390/microorganisms10122436.

The Role of the Gut Microbiome in Psychiatric Disorders

Ioana-Maria Andrioaie  1   2 , Alexandru Duhaniuc  1   2 , Eduard Vasile Nastase  2   3 , Luminița Smaranda Iancu  1   4 , Cătălina Luncă  1   5 , Felicia Trofin  1   2 , Dana-Teodora Anton-Păduraru  5   6 , Olivia-Simona Dorneanu  1   2
Affiliations
Review

The Role of the Gut Microbiome in Psychiatric Disorders

Ioana-Maria Andrioaie et al. Microorganisms. .

Abstract

The role of the gut microbiome in mental health has been of great interest in the past years, with several breakthroughs happening in the last decade. Its implications in several psychiatric disorders, namely anxiety, depression, autism and schizophrenia, are highlighted. In this review were included relevant studies on rodents, as well as human studies. There seems to be a connection between the gut microbiome and these pathologies, the link being emphasized both in rodents and humans. The results obtained in murine models align with the results acquired from patients; however, fewer studies regarding anxiety were conducted on humans. The process of sequencing and analyzing the microbiome has been conducted in humans for several other pathologies mentioned above. Additionally, the possible beneficial role of probiotics and postbiotics administered as an aid to the psychiatric medication was analyzed.

Keywords: anxiety; autism; depression; gut microbiome; microbiota–gut–brain axis; probiotics; psychiatric disorders; schizophrenia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

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The selection process of the articles.
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