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Review
. 2022 Dec 10;14(24):5273.
doi: 10.3390/nu14245273.

Resveratrol against Cervical Cancer: Evidence from In Vitro and In Vivo Studies

Matteo Nadile  1 , Maria Ilektra Retsidou  2 , Katerina Gioti  2 , Apostolos Beloukas  2   3 , Evangelia Tsiani  1   4
Affiliations
Review

Resveratrol against Cervical Cancer: Evidence from In Vitro and In Vivo Studies

Matteo Nadile et al. Nutrients. .

Abstract

Cervical cancer affects many women worldwide, with more than 500,000 cases diagnosed and approximately 300,000 deaths each year. Resveratrol is a natural substance of the class of phytoalexins with a basic structure of stilbenes and has recently drawn scientific attention due to its anticancer properties. The purpose of this review is to examine the effectiveness of resveratrol against cervical cancer. All available in vitro and in vivo studies on cervical cancer were critically reviewed. Many studies utilizing cervical cancer cells in culture reported a reduction in proliferation, cell cycle arrest, and induction of apoptosis. Apart from apoptosis, induction of autophagy was seen in some studies. Importantly, many studies have shown a reduction in the HPV oncoproteins E6 and E7 and increased levels of the tumor suppressor p53 with resveratrol treatment. A few studies examined the effects of resveratrol administration in mice ectopic-xenografted with cervical cancer cells showing reduced tumor volume and weight. Overall, the scientific data show that resveratrol has the ability to target/inhibit certain signaling molecules (EGFR, VEGFR, PKC, JNK, ERK, NF-kB, and STAT3) involved in cervical cancer cell proliferation and survival. Further in vivo experiments and clinical studies are required to better understand the potential of resveratrol against cervical cancer.

Keywords: apoptosis; cervical cancer; proliferation; resveratrol; signaling cascades; survival.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Chemical structure of resveratrol, a polyphenolic stilbene found in high concentration in grapes and red wine.
Figure 2
Figure 2
Summary of the effects of resveratrol in cervical cancer cells in vitro. RSV reduced proliferation and survival and induced apoptosis of cervical cancer cells. The figure, created using BioRender.com, is based on the data of the studies [36,37,38,39,40,41,42,43,44,45,46,47,48,49,50,51,52,53,54,55,56,57,58,59,60,61,62].
Figure 3
Figure 3
Summary of the effects of resveratrol in cervical cancer in animals. Treatment of animals (mice) xenografted with cervical cancer cells with RSV resulted in a significant reduction in tumor volume and weight compared to non-treated mice. The figure, created using BioRender.com, is based on the data of the studies [52,56,59,67,69].
See this image and copyright information in PMC

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