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. 2022 Dec 11;14(24):5282.
doi: 10.3390/nu14245282.

Nutritional Status and Selected Adipokines in Children with Irritable Bowel Syndrome

Wojciech Roczniak  1 , Agnieszka Szymlak  2 , Bogdan Mazur  3 , Agata Chobot  4 , Małgorzata Stojewska  5 , Joanna Oświęcimska  1
Affiliations

Nutritional Status and Selected Adipokines in Children with Irritable Bowel Syndrome

Wojciech Roczniak et al. Nutrients. .

Abstract

Background: The aim of this study was to assess the nutritional status and serum concentrations of adipokines in children with irritable bowel syndrome (IBS) and healthy controls. We also sought to evaluate their relation to metabolic parameters.

Methods: We studied 33 IBS patients (11 girls, 22 boys) aged 5-17 years and 30 healthy age-matched controls (11 girls, 19 boys). The analysis included anthropometric measurements, body composition parameter measurements using bioimpedance, and biochemical tests and measurements of serum concentrations of leptin, adiponectin, chemerin, and omentin-1.

Results: The results of the anthropometric measurements were comparable between the patients and the controls. The patients had higher triglycerides, HOMA-IRs, and chemerin concentrations than the healthy subjects. The HDL cholesterol and omentin-1 levels were lower than in the controls. Leptin and adiponectin did not differ significantly between the groups. An analysis of the receiver operator curves (ROCs) showed that serum concentrations of chemerin ≥ 232.8 ng/mL had 30% sensitivity and 87% specificity when they were used to differentiate between children with IBS and healthy subjects. In the case of serum omentin-1 concentrations ≤ 279.4 ng/mL, the sensitivity and specificity were 60% and 80%, respectively.

Conclusions: The nutritional status of children with IBS did not differ from that of the healthy controls. We found significant differences in serum chemerin and omentin-1 concentrations between IBS patients and healthy children. These adipokines could be used as IBS biomarkers as they demonstrate good specificity and moderate sensitivity. The serum concentrations of chemerin and omentin-1 in IBS patients were related to nutritional status and insulin resistance.

Keywords: adiponectin; chemerin; children; irritable bowel syndrome; leptin; omentin-1.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Mean leptin levels in children with irritable bowel syndrome (IBS; n = 33) and controls (C; n = 30).
Figure 2
Figure 2
Mean adiponectin levels in children with irritable bowel syndrome (IBS; n = 33) and controls (C; n = 30).
Figure 3
Figure 3
Mean chemerin levels in children with irritable bowel syndrome (IBS; n = 33) and controls (C; n = 30), * p = 0.03.
Figure 4
Figure 4
Mean omentin-1 levels in children with irritable bowel syndrome (IBS; n = 33) and controls (C; n = 30), * p = 0.04.
Figure 5
Figure 5
ROC plot for chemerin concentrations (cut-off point: 232.8 ng/mL; sensitivity: 0.39; specificity: 0.87; efficiency: 0.76).
Figure 6
Figure 6
ROC plot for chemerin concentrations (cut-off point: 232.8 ng/mL; sensitivity: 0.60; specificity: 0.80; efficiency: 0.64).
See this image and copyright information in PMC

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