Case Reports
doi: 10.1007/BF00314091.
Progressive multifocal leucoencephalopathy with magnetic resonance imaging verification and therapeutic trials with interferon
Affiliations
- PMID: 3655847
- DOI: 10.1007/BF00314091
Item in Clipboard
Case Reports
Progressive multifocal leucoencephalopathy with magnetic resonance imaging verification and therapeutic trials with interferon
J Neurol.
1987 Aug.
Abstract
Progressive multifocal leucoencephalopathy was diagnosed by magnetic resonance imaging (MRI) and brain biopsy in a 44-year-old woman, for whom therapeutic trials with various antiviral agents were made. Despite early diagnosis and treatment, her neurological deterioration and extension of MRI-detectable lesions were not halted for a period of about 8 months. After the introduction of intrathecal beta-interferon therapy, her neurological status and MRI findings became stable and showed minimal improvement. Early diagnosis of this fatal disorder is important and intrathecal interferon therapy should be considered.
Similar articles
-
Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon.Ann Neurol. 1993 Apr;33(4):407-11. doi: 10.1002/ana.410330415. Ann Neurol. 1993. PMID: 7683856
-
Inefficacy of cytarabine in progressive multifocal leucoencephalopathy in AIDS.Lancet. 1993 Sep 4;342(8871):622-3. doi: 10.1016/0140-6736(93)91453-s. Lancet. 1993. PMID: 8102756 Clinical Trial. No abstract available.
-
Progressive multifocal leukoencephalopathy: failure of cytarabine therapy.Neurology. 1982 Feb;32(2):200-3. doi: 10.1212/wnl.32.2.200. Neurology. 1982. PMID: 7198746 No abstract available.
-
Progressive multifocal leukoencephalopathy: clinical and MR response to treatment.AJNR Am J Neuroradiol. 1996 Mar;17(3):597-600. AJNR Am J Neuroradiol. 1996. PMID: 8881262 Free PMC article. Review.
-
[A case of progressive multifocal leukoencephalopathy presenting white matter MRI lesions extending over the cerebral cortex and a marked decrease in cerebral blood flow on SPECT, and associated with HTLV-I infection].Rinsho Shinkeigaku. 2005 Jun;45(6):426-30. Rinsho Shinkeigaku. 2005. PMID: 16022467 Review. Japanese.
Cited by
-
Progressive multifocal leukoencephalopathy in AIDS: are there any MR findings useful to patient management and predictive of patient survival? AIDS Clinical Trials Group, 243 Team.AJNR Am J Neuroradiol. 1999 Nov-Dec;20(10):1896-906. AJNR Am J Neuroradiol. 1999. PMID: 10588116 Free PMC article. Clinical Trial.
-
Progressive multifocal leukoencephalopathy in HIV-1 infection.Lancet Infect Dis. 2009 Oct;9(10):625-36. doi: 10.1016/S1473-3099(09)70226-9. Lancet Infect Dis. 2009. PMID: 19778765 Free PMC article. Review.
-
Natalizumab and progressive multifocal leucoencephalopathy.Ann Rheum Dis. 2006 Nov;65 Suppl 3(Suppl 3):iii48-53. doi: 10.1136/ard.2006.058404. Ann Rheum Dis. 2006. PMID: 17038473 Free PMC article. Review.
-
Progressive multifocal leukoencephalopathy in AIDS: a clinicopathologic study and review of the literature.J Neurol. 1993 Jul;240(7):391-406. doi: 10.1007/BF00867351. J Neurol. 1993. PMID: 8410079 Review.
-
Interferon- alpha and - beta restrict polyomavirus JC replication in primary human fetal glial cells: implications for progressive multifocal leukoencephalopathy therapy.J Infect Dis. 2007 Sep 1;196(5):712-8. doi: 10.1086/520518. Epub 2007 Jul 20. J Infect Dis. 2007. PMID: 17674314 Free PMC article.