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Review
. 2022 Dec 15;14(24):5323.
doi: 10.3390/nu14245323.

Gut Microbiota in Non-Alcoholic Fatty Liver Disease Patients with Inflammatory Bowel Diseases: A Complex Interplay

Ludovico Abenavoli  1 , Lidia Giubilei  1 , Anna Caterina Procopio  1 , Rocco Spagnuolo  1 , Francesco Luzza  1 , Luigi Boccuto  2 , Emidio Scarpellini  3
Affiliations
Review

Gut Microbiota in Non-Alcoholic Fatty Liver Disease Patients with Inflammatory Bowel Diseases: A Complex Interplay

Ludovico Abenavoli et al. Nutrients. .

Abstract

The intestinal microbiota represents the microbial community that colonizes the gastrointestinal tract and constitutes the most complex ecosystem present in nature. The main intestinal microbial phyla are Firmicutes, Bacteroidetes, Actinobacteria, Proteobacteria, Fusobacteria, and Verrucromicrobia, with a clear predominance of the two phyla Firmicutes and Bacteroidetes which account for about 90% of the intestinal phyla. Intestinal microbiota alteration, or dysbiosis, has been proven to be involved in the development of various syndromes, such as non-alcoholic fatty liver disease, Crohn's disease, and ulcerative colitis. The present review underlines the most recurrent changes in the intestinal microbiota of patients with NAFLD, Crohn's disease, and ulcerative colitis.

Keywords: Crohn’s disease; microbiota; non-alcoholic fatty liver disease; ulcerative colitis.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Increase in intestinal permeability, oxidative stress (e.g., starting of inflammatory response with intestinal mucosa damage), endotoxemia (namely, lipopolysaccharide concentration) and gut dysbiosis in IBD patients, involved in the onset and development of NAFLD. ↑ increased abundance; ↓ decreased abundance; * shared gut dysbiosis between NAFLD and IBD patients.
See this image and copyright information in PMC

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