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Review
. 2022 Dec 6;11(12):1481.
doi: 10.3390/pathogens11121481.

Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Jyoti S Mathad  1   2 , Sharan Yadav  1 , Arthi Vaidyanathan  1 , Amita Gupta  3 , Sylvia M LaCourse  4
Affiliations
Review

Tuberculosis Infection in Pregnant People: Current Practices and Research Priorities

Jyoti S Mathad et al. Pathogens. .

Abstract

Women are significantly more likely to develop tuberculosis (TB) disease within the first 90 days after pregnancy than any other time in their lives. Whether pregnancy increases risk of progression from TB infection (TBI) to TB disease is unknown and is an active area of investigation. In this review, we discuss the epidemiology of TB and TBI in pregnancy, TBI diagnostics, and prevalence in pregnancy. We also review TBI treatment and highlight research priorities, such as short-course TB prevention regimens, drug-resistant TB prevention, and additional considerations for safety, tolerability, and pharmacokinetics that are unique to pregnant and postpartum people.

Keywords: HIV; isoniazid; postpartum; pregnant; prevention; tuberculosis.

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Conflict of interest statement

The authors declare no conflict of interest.

References

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