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Review
. 2022 Nov 30;14(12):2652.
doi: 10.3390/pharmaceutics14122652.

Extracellular Vesicle-Based Therapeutics in Neurological Disorders

Yiwen Yuan  1 , Jian Sun  1 , Tongyao You  1 , Weiwei Shen  1 , Wenqing Xu  1 , Qiang Dong  1   2 , Mei Cui  1   2
Affiliations
Review

Extracellular Vesicle-Based Therapeutics in Neurological Disorders

Yiwen Yuan et al. Pharmaceutics. .

Abstract

Neurological diseases remain some of the major causes of death and disability in the world. Few types of drugs and insufficient delivery across the blood-brain barrier limit the treatment of neurological disorders. The past two decades have seen the rapid development of extracellular vesicle-based therapeutics in many fields. As the physiological and pathophysiological roles of extracellular vesicles are recognized in neurological diseases, they have become promising therapeutics and targets for therapeutic interventions. Moreover, advanced nanomedicine technologies have explored the potential of extracellular vesicles as drug delivery systems in neurological diseases. In this review, we discussed the preclinical strategies for extracellular vesicle-based therapeutics in neurological disorders and the struggles involved in their clinical application.

Keywords: drug delivery; extracellular vesicles; mesenchymal stem cells; neurodegenerative diseases; neurological disorders; therapeutics.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Figure 1
Figure 1
Strategies for EV-based therapeutics in neurological diseases. NSCs, neural stem cells; MSCs, mesenchymal stromal cells; DCs, dendritic cells; Mϕ, macrophage; BBB, blood–brain barrier; miRNA, microRNA; EVs, extracellular vesicles.
See this image and copyright information in PMC

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