Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2022 Dec 5;14(12):2722.
doi: 10.3390/pharmaceutics14122722.

Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro

Anna-Lena Elksnat  1 , Paula Zscherpe  2 , Karina Klein  2 , Jessika Maximiliane Cavalleri  3 , Jessica Meißner  1
Affiliations

Effect of an Oxygen-Based Mechanical Drug Delivery System on Percutaneous Permeation of Various Substances In Vitro

Anna-Lena Elksnat et al. Pharmaceutics. .

Abstract

Transdermal drug administration is an elegant method to overcome various side effects of oral or parenteral drug administration. Nevertheless, due to an effective skin barrier, which is provided by the stratum corneum, transdermal drug delivery is sometimes very slow and ineffective. Thus, the effect of a medical device (DERMADROP TDA) for transdermal penetration of drugs in conjunction with a special vehicle emulsion on percutaneous permeation of several substances (with different physicochemical properties) was investigated in Franz-type diffusion cells with porcine skin over 28 h. This medical device disperses pharmaceutical agents via oxygen flow through an application system, which is used in conjunction with specially developed vehicle substances. Substance permeation of various substances with different physicochemical properties (diclofenac, enrofloxacin, flufenamic acid, indomethacin, and salicylic acid) was examined after application with a pipette and with the medical device. Therefore, acceptor media samples were collected up to 28 h after drug administration. Drug concentration in the acceptor medium was determined via high-performance liquid chromatography. Enhanced permeation was observed for diclofenac, enrofloxacin, flufenamic acid, indomethacin, and salicylic acid after oxygen-based administration. This correlates negatively with the molecular weight. Thus, drug administration can effectively be enhanced by a medical device using oxygen.

Keywords: Franz-type diffusion cell; oxygen; permeation enhancer; porcine skin; skin absorption; transdermal drug delivery.

PubMed Disclaimer

Conflict of interest statement

The MEDDROP device and the Matrix A TDA-cartridges were kindly provided by Meddrop BioMedical Technologies GmbH, Hamburg, Germany. The funders had no role in the design of the study, in the collection, analyses, or data interpretation, in the writing of the manuscript, or in the decision to publish the results.

Figures

Figure 1
Figure 1
DERMADROP TDA system; (1) applicator tip, (2) TDA pen, (3) cartridge case, (4) cartridge, (5) applicator body, (6) DERMADROP device.
Figure 2
Figure 2
Cumulative amount of the different drugs after application via DERMADROP TDA and via pipette (control) over 28 h. (a) Diclofenac; (b) enrofloxacin; (c) flufenamic acid; (d) indomethacin; and (e) salicylic acid. Data are shown as mean ± SEM; n = 6.
Figure 3
Figure 3
Histological section of porcine skin treated with 16 µL Matrix TDA via the medical device DERMADROP TDA (left) and pipette (right). HE-stained, 10 µm thin skin sections cut transversal to skin surface; bar represents 100 µm.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Williams A.C., Barry B.W. Penetration enhancers. Adv. Drug Deliv. Rev. 2004;56:603–618. doi: 10.1016/j.addr.2003.10.025. - DOI - PubMed
    1. Mueller J., Trapp M., Neubert R.H.H. The effect of hydrophilic penetration/diffusion enhancer on stratum corneum lipid models: Part II: DMSO. Chem. Phys. Lipids. 2019;225:104816. doi: 10.1016/j.chemphyslip.2019.104816. - DOI - PubMed
    1. Newton S.J. Chemical penetration enhancers. Int. J. Pharm. Compd. 2013;17:370–374. - PubMed
    1. Raphael A.P., Wright O.R., Benson H.A., Prow T.W. Recent advances in physical delivery enhancement of topical drugs. Curr. Pharm. Des. 2015;21:2830–2847. doi: 10.2174/1381612821666150428144852. - DOI - PubMed
    1. Brown M.B., Martin G.P., Jones S.A., Akomeah F.K. Dermal and transdermal drug delivery systems: Current and future prospects. Drug Deliv. 2006;13:175–187. doi: 10.1080/10717540500455975. - DOI - PubMed

LinkOut - more resources