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Review
. 2022 Dec 13;14(24):5445.
doi: 10.3390/polym14245445.

Advances in Polymeric Colloids for Cancer Treatment

Imran Ali  1 , Sara H Althakfi  2 , Mohammad Suhail  3 , Marcello Locatelli  4 , Ming-Fa Hsieh  5 , Mosa Alsehli  6 , Ahmed M Hameed  2
Affiliations
Review

Advances in Polymeric Colloids for Cancer Treatment

Imran Ali et al. Polymers (Basel). .

Abstract

Polymer colloids have remarkable features and are gaining importance in many areas of research including medicinal science. Presently, the innovation of cancer drugs is at the top in the world. Polymer colloids have been used as drug delivery and diagnosis agents in cancer treatment. The polymer colloids may be of different types such as micelles, liposomes, emulsions, cationic carriers, and hydrogels. The current article describes the state-of-the-art polymer colloids for the treatment of cancer. The contents of this article are about the role of polymeric nanomaterials with special emphasis on the different types of colloidal materials and their applications in targeted cancer therapy including cancer diagnoses. In addition, attempts are made to discuss future perspectives. This article will be useful for academics, researchers, and regulatory authorities.

Keywords: cancer diagnosis and treatment; colloidal polymeric nanomaterials; future perspectives; polymer colloids.

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Conflict of interest statement

There is no conflict of interest in this manuscript.

Figures

Figure 1
Figure 1
The influence of the poloxamer structure on the interfacial and macroscopic properties of nano-emulsions [35].
Figure 2
Figure 2
Synthetic Route of (a): p-MTX conjugates and (b): the formation of p-MTX micelles and MTX-loaded p–MTX micelles [40].
Figure 3
Figure 3
FESEM images of docetaxel-loaded PLGA–TPGS/Poloxamer 235 nanoparticles and microparticles. (A) nanoparticles; (B) microparticles [41].
Figure 4
Figure 4
The cell viabilities of TE 354.T with L4, L4-5FU-15, L4Apt, L4Apt-5FU-15 with 25, 50, 75, and 100 µg lipids/mL doses for (a): 24 h and (b): 48 h and (c): 5-FU with 25, 50, 75, and 100 µg drug/mL doses for 24 and 48 h [106].
Figure 4
Figure 4
The cell viabilities of TE 354.T with L4, L4-5FU-15, L4Apt, L4Apt-5FU-15 with 25, 50, 75, and 100 µg lipids/mL doses for (a): 24 h and (b): 48 h and (c): 5-FU with 25, 50, 75, and 100 µg drug/mL doses for 24 and 48 h [106].
Figure 5
Figure 5
The in vitro cell viabilities of the different formulations in SkinEthic™ RHE tissues [107].
Figure 6
Figure 6
Structure of (a) micelle and (b) encapsulated nano-carriers.
See this image and copyright information in PMC

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