Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative

Bahaa Abu-Raya^{1

2}, Kevin Forsyth³, Scott A Halperin⁴, Kirsten Maertens⁵, Christine E Jones^{6

7}, Ulrich Heininger⁸, Daniela Hozbor⁹, Carl Heinz Wirsing von König¹⁰, Amar J Chitkara¹¹, Rudzani Muloiwa¹², Tina Q Tan¹³

Affiliations

¹ BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.
² Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
³ College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.
⁴ Canadian Center for Vaccinology, Departments of Pediatrics and Microbiology and Immunology, Dalhousie University, Izaak Walton Killam Health Centre, and Nova Scotia Health Authority, Halifax, NS B3H 4R2, Canada.
⁵ Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, 2610 Antwerp, Belgium.
⁶ Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
⁷ NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
⁸ Pediatric Infectious Diseases, University of Basel Children's Hospital, 4056 Basel, Switzerland.
⁹ Instituto de Biotecnología y Biología Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, La Plata 1900, Argentina.
¹⁰ Independent Researcher, 47805 Krefeld, Germany.
¹¹ Department of Pediatrics, Max Super Speciality Hospital, New Delhi 110017, India.
¹² Department of Paediatrics and Child health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.
¹³ Feinberg School of Medicine, Northwestern University, Chicago, IL 60208, USA.

PMID: 36560400
PMCID: PMC9786323
DOI: 10.3390/vaccines10121990

Review

Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative

Bahaa Abu-Raya et al. Vaccines (Basel). 2022.

. 2022 Nov 23;10(12):1990.

doi: 10.3390/vaccines10121990.

Authors

Affiliations

¹ BC Children's Hospital Research Institute, Vancouver, BC V5Z 4H4, Canada.
² Department of Pediatrics, University of British Columbia, Vancouver, BC V6H 3V4, Canada.
³ College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.
⁴ Canadian Center for Vaccinology, Departments of Pediatrics and Microbiology and Immunology, Dalhousie University, Izaak Walton Killam Health Centre, and Nova Scotia Health Authority, Halifax, NS B3H 4R2, Canada.
⁵ Centre for the Evaluation of Vaccination, Vaccine and Infectious Diseases Institute, University of Antwerp, 2610 Antwerp, Belgium.
⁶ Faculty of Medicine and Institute for Life Sciences, University of Southampton, Southampton SO17 1BJ, UK.
⁷ NIHR Southampton Clinical Research Facility and NIHR Southampton Biomedical Research Centre, University Hospital Southampton NHS Foundation Trust, Southampton SO16 6YD, UK.
⁸ Pediatric Infectious Diseases, University of Basel Children's Hospital, 4056 Basel, Switzerland.
⁹ Instituto de Biotecnología y Biología Molecular, Facultad de Ciencias Exactas, Universidad Nacional de La Plata, CONICET, La Plata 1900, Argentina.
¹⁰ Independent Researcher, 47805 Krefeld, Germany.
¹¹ Department of Pediatrics, Max Super Speciality Hospital, New Delhi 110017, India.
¹² Department of Paediatrics and Child health, Faculty of Health Sciences, University of Cape Town, Cape Town 7935, South Africa.
¹³ Feinberg School of Medicine, Northwestern University, Chicago, IL 60208, USA.

PMID: 36560400
PMCID: PMC9786323
DOI: 10.3390/vaccines10121990

Abstract

Infants are at high risk for severe morbidity and mortality from pertussis disease during early infancy. Vaccination against pertussis in pregnancy has emerged as the ideal strategy to protect infants during these early, vulnerable, first months of life. On 30 November and 1 December 2021, the Global Pertussis Initiative held a meeting that aimed to discuss and review the most up-to-date scientific literature supporting vaccination against pertussis in pregnancy and outstanding scientific questions. Herein, we review the current and historically published literature and summarize the findings as consensus statements on vaccination against pertussis in pregnancy on behalf of the Global Pertussis Initiative.

Keywords: Global Pertussis Initiative; immunity; pertussis; pregnancy; protection; vaccination.

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Conflict of interest statement

The authors are scientific experts and, as such, received honoraria for their participation in this live meeting from Sanofi. In addition, Heininger, U., was a member of the Collaboration of European Experts on Pertussis Awareness Generation (CEEPAG; he was a group member until 2021), and he has received honoraria for participation in previously associated live meetings from Sanofi, USA and Sanofi, France, respectively, as well as receiving honoraria for educational activities from Pfizer, MSD, and InfectoPharm. Forsyth, K., and Chitkara, A.J., have also previously received honoraria from Sanofi. Tan, T.Q., has received grants from Merck and Sanofi and personal fees from GSK Biologicals and Sanofi, and honoraria from Sanofi. Wirsing von König, C.H., has received honoraria for attending meetings sponsored by Sanofi, GSK Biologicals SA, MSD, and Novartis Vaccines. Halperin, S.A., has received contracts for clinical trials and served on ad hoc advisory boards for Sanofi and GSK. Muloiwa, R., has received honoraria for educational activities from MSD and Sanofi. The authors declare no other conflict of interest.

References

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1. Abu-Raya B., Bettinger J.A., Vanderkooi O.G., Vaudry W., Halperin S.A., Sadarangani M., Members of the Canadian Immunization Monitoring Program, Active (IMPACT) Burden of Children Hospitalized With Pertussis in Canada in the Acellular Pertussis Vaccine Era, 1999–2015. J. Pediatric Infect. Dis. Soc. 2020;9:118–127. doi: 10.1093/jpids/piy128. - DOI - PMC - PubMed

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Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative

Affiliations

Vaccination in Pregnancy against Pertussis: A Consensus Statement on Behalf of the Global Pertussis Initiative

Authors

Affiliations

Abstract

Conflict of interest statement

References

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