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Review
. 2023 Mar 1;29(2):96-103.
doi: 10.1097/MCP.0000000000000935. Epub 2022 Dec 23.

Vitamin D deficiency in chronic obstructive pulmonary disease

Monica L L Mullin  1 , Stephen Milne  1   2   3
Affiliations
Review

Vitamin D deficiency in chronic obstructive pulmonary disease

Monica L L Mullin et al. Curr Opin Pulm Med. .

Abstract

Purpose of review: There is biological and epidemiological evidence supporting a role for vitamin D in the respiratory system, and vitamin D deficiency (VDD) may be associated with poor health outcomes in people with chronic obstructive pulmonary disease (COPD). This review summarizes recent findings relevant to the role of vitamin D in COPD.

Recent findings: The prevalence of VDD in people with COPD may be underestimated. Treatment of severe VDD [serum 25(OH)D3 < 10 ng/ml] may reduce the risk of COPD exacerbations. Vitamin D supplementation may also improve functional capacity and quality of life in people with COPD. However, there is no strong evidence that vitamin D supplementation slows the decline in lung function.

Summary: Although there are many known associations between vitamin D and COPD outcomes, the causal nature of these associations and the precise benefits of vitamin D supplementation remain unclear. High-quality randomized controlled trials are necessary.

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